Chemical composition and antiproliferative activity of Croton campestris A.St.-Hil. essential oil

Author(s)

Monteiro, Paula Araujo ^{[1, 2]} ; Maccari Zelioli, Icaro Augusto ^[2] ; de Oliveira Sousa, Ilza Maria ^[2] ; Tasca Gois Ruiz, Ana Lucia ^[3] ; Vendramini-Costa, Debora Barbosa ^{[2, 4]} ; Foglio, Mary Ann ^{[2, 3]} ; de Carvalho, Joao Ernesto ^{[2, 3]}

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Inst Biol, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, UNICAMP, CPQBA, Chem Biol & Agr Res Ctr, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, UNICAMP, Fac Pharmaceut Sci, Campinas, SP - Brazil

^[4] Fox Chase Canc Ctr, Canc Biol Program, 333 Cottman Ave, Philadelphia, PA 19111 - USA

• Document type: Journal article
• Source: NATURAL PRODUCT RESEARCH; v. 33, n. 4, p. 580-583, FEB 16 2019.
• Web of Science Citations: 1

Abstract

Herein, the antiproliferative potential of the essential oil obtained from fresh leaves of Croton campestris against human tumour cell lines was investigated for the first time. Furthermore, the essential oil obtained by hydrodistillation had the composition determined by gas chromatography-mass spectrometry (GC/MS). Ten major components were identified that comprised 91.59% of the total content, with 23.8% consisting of (Z)-caryophyllene and 16.08% consisting of gamma-elemene as main components. The cytotoxic activity was observed mainly for breast (MCF-7) and colon (HT-29) human tumour cell lines, with GI(50) (50% growth inhibition) concentration of 8.61 and 9.94 mu g/mL, respectively. The results of this study showed that the essential oil obtained from Croton campestris A.St.-Hil. represents a potential source for the search of new antitumour agents. {[}GRAPHICS] . (AU)

• FAPESP's process: 11/22457-7 - Isolation, identification and mechanism of action of anticancer active principles of Croton campestris A.St.-Hil.
• Grantee: Paula Araujo Monteiro
• Support Opportunities: Scholarships in Brazil - Doctorate