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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of magnitude of visceral adipose tissue reduction: Impact on insulin resistance, hyperleptinemia and cardiometabolic risk in adolescents with obesity after long-term weight-loss therapy

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Author(s):
da Silveira Campos, Raquel Munhoz [1, 2] ; Landi Masquio, Deborah Cristina [3] ; Corgosinho, Flavia Campos [4] ; Caranti, Danielle Arisa [1, 5] ; Ganen, Aline de Piano [3] ; Tock, Lian [6] ; Oyama, Lila Missae [7, 8] ; Damaso, Ana Raimunda [7]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Biosci, Santos - Brazil
[2] Univ Fed Sao Carlos, Dept Physiotherapy, Therapeut Resources Lab, Sao Carlos, SP - Brazil
[3] Sao Camilo Univ Ctr, Sao Paulo - Brazil
[4] Univ Fed Goias, Goiania, Go - Brazil
[5] Univ Fed Sao Paulo UNIFESP, Post Grad Program Interdisciplinary Hlth Sci, Santos - Brazil
[6] Weight Sci, Sao Paulo - Brazil
[7] Univ Fed Sao Paulo UNIFESP, Paulista Sch Med, Post Grad Program Nutr, Sao Paulo - Brazil
[8] Univ Fed Sao Paulo, Paulista Sch Med, Dept Physiol, Sao Paulo - Brazil
Total Affiliations: 8
Document type: Journal article
Source: Diabetes & Vascular Disease Research; v. 16, n. 2, SI, p. 196-206, MAR 2019.
Web of Science Citations: 1
Abstract

Aim: To investigate the association between visceral adipose tissue loss and insulin resistance and hyperleptinemia in adolescents with obesity submitted to interdisciplinary weight-loss therapy. Methods: A total of 172 post-pubertal adolescents (body mass index greater than the 95th percentile of the Centers for Disease Control and Prevention reference growth charts) were recruited for the study. The adolescents were assigned to long-term weight-loss therapy. Body composition, visceral and subcutaneous fat, glucose metabolism, lipid profile, hepatic enzymes and leptin concentration were measured. After the therapy, the adolescents were allocated to three different groups according to the tertile of visceral fat reduction. Results: Positive effects on body composition were observed in all analysed groups independent of visceral fat reduction. It was found that visceral fat was an independent predictor of insulin resistance in the investigated population. Obese adolescents who lost a higher proportion of visceral adipose tissue (>1.8 cm) demonstrated improved metabolic and inflammatory parameters twice as much than those who presented smaller losses. Positive correlations between visceral fat reduction and glucose metabolism, lipid profile, hepatic enzymes and homeostasis model assessment of insulin resistance index were demonstrated. Conclusion: The magnitude of the reduction in visceral fat was an independent predictor of insulin resistance, hyperleptinemia and metabolic disorders related to obese adolescents. (AU)

FAPESP's process: 17/07372-1 - New frontiers in the fight against obesity: digital health education as supporting in the interdisciplinary clinical process
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants
FAPESP's process: 15/14309-9 - Effects of physical exercise associate with phototherapy on adipogenesis biomarkers and transdifferentiation of adipose tissue in adult obese women
Grantee:Raquel Munhoz da Silveira Campos
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/08522-6 - New therapeutic perspectives in obesity
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants
FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants