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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exploring the Immunological Mechanisms Underlying the Anti-vascular Endothelial Growth Factor Activity in Tumors

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Author(s):
de Aguiar, Rodrigo Barbosa [1] ; de Moraes, Jane Zveiter [1]
Total Authors: 2
Affiliation:
[1] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: FRONTIERS IN IMMUNOLOGY; v. 10, MAY 9 2019.
Web of Science Citations: 1
Abstract

Several studies report the key role of the vascular endothelial growth factor (VEGF) signaling on angiogenesis and on tumor growth. This has led to the development of a number of VEGF-targeted agents to treat cancer patients by disrupting the tumor blood vessel supply. Of them, bevacizumab, an FDA-approved humanized monoclonal antibody against VEGF, is the most promising. Although the use of antibodies targeting the VEGF pathway has shown clinical bene fits associated with a reduction in the tumor blood vessel density, the inhibition of VEGF-driven vascular effects is only part of the functional mechanism of these therapeutic agents in the tumor ecosystem. Compelling reports have demonstrated that VEGF confers, in addition to the activation of angiogenesis-related processes, immunosuppressive properties in tumors. It is also known that structural remodeling of the tumor blood vessel bed by anti-VEGF approaches affect the in flux and activation of immune cells into tumors, which might influence the therapeutic results. Besides that, part of the therapeutic effects of antiangiogenic antibodies, including their role in the tumor vascular network, might be triggered by Fc receptors in an antigen-independent manner. In this mini-review, we explore the role of VEGF inhibitors in the tumor microenvironment with focus on the immune system, discussing around the functional contribution of both bevacizumab's Fab and Fc domains to the therapeutic results and the combination of bevacizumab therapy with other immune-stimulatory settings, including adjuvant-based vaccine approaches. (AU)

FAPESP's process: 09/18631-1 - STUDY OF ANTIBODIES FOR INHIBITION OF ANGIOGENESIS IN MELANOMA
Grantee:Jane Zveiter de Moraes
Support Opportunities: Regular Research Grants