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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Incorporation of chlorhexidine and nano-sized sodium trimetaphosphate into a glass-ionomer cement: Effect on mechanical and microbiological properties and inhibition of enamel demineralization

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Author(s):
Rodrigues da Silva, Marjully Eduardo [1] ; Danelon, Marcelle [1] ; Santos Souza, Jose Antonio [1] ; Silva, Dinah Fressato [1] ; Pereira, Jesse Augusto [1] ; Pedrini, Denise [2] ; de Camargo, Emerson Rodrigues [3] ; Botazzo Delbem, Alberto Carlos [1] ; Duque, Cristiane [1]
Total Authors: 9
Affiliation:
[1] Sao Paulo State Univ Unesp, Sch Dent, Dept Pediat Dent & Publ Hlth, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Dent, Dept Surg & Integrated Clin, Aracatuba, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Chem, Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Dentistry; v. 84, p. 81-88, MAY 2019.
Web of Science Citations: 0
Abstract

Objective: To evaluate the antimicrobial/antibiofilm and mechanical properties, and the effect on enamel demineralization of a resin-modified GIC (RMGIC) containing CHX and nano-sized sodium trimetaphosphate (TMP). Methods: RMGIC was associated with CHX (1.25 or 2.5%) and/or TMP (7 or 14%). Antimicrobial and antibiofilm activity were assessed using agar diffusion test and evaluation of biofilm metabolism, respectively. In addition, fluoride (F) and TMP releases as well as the diametral tensile (DTS) and compressive (CS) strength were determined. The percentage of mineral loss (%SH), integrated loss of subsurface hardness (Delta KHN) and enamel F concentrations were also evaluated. Results: RMGICs containing CHX associated or not with TMP presented higher inhibition zones and effect on S. mutans biofilm. A reduction on CS was observed only for RMGIC + 2.5%CHX and on DTS for RMGIC + 2.5%CHX + 14%TMP. The highest F and TMP releases and lowest %SH and Delta KHN values were detected for RMGIC + 1.25%CHX + 14%TMP and RMGIC + 2.5%CHX + 14%TMP. Higher enamel F concentrations were observed for TMP groups. Conclusion: 1.25%CHX and 14%TMP increased antimicrobial/antibiofilm action and the ability to prevent enamel demineralization, with minimal effect on the mechanical properties of RMGIC. Clinical significance: RMGIC containing CHX and TMP is an alternative material for patients at high risk for dental caries and can be indicated for low-stress regions or provisional restorations. (AU)

FAPESP's process: 14/03174-2 - Effect of combination of inorganic phosphate and chlorhexidine on enamel demineralization process and microbiological and mechanical properties of glass ionomer cements
Grantee:Dinah Fressato Silva
Support Opportunities: Scholarships in Brazil - Scientific Initiation