Phosphodiesterase type 5 inhibitors improve microvascular dysfunction markers in pulmonary arterial hypertension associated with congenital heart disease

Author(s)

Clave, Mariana M. ^[1] ; Maeda, Nair Y. ^[2] ; Thomaz, Ana M. ^[1] ; Bydlowski, Sergio P. ^[3] ; Lopes, Antonio A. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Med, Heart Inst, Sao Paulo - Brazil

^[2] Pro Sangue Fdn, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, LIM 31, Sao Paulo - Brazil

• Document type: Journal article
• Source: CONGENITAL HEART DISEASE; v. 14, n. 2, p. 246-255, MAR-APR 2019.
• Web of Science Citations: 2

Abstract

Background Ideally, vasodilator therapies for pulmonary arterial hypertension (PAH) should have a favorable impact on markers of vascular dysfunction, in addition to their known effects on hemodynamics, cardiac function, and patient's physical capacity. Methods We analyzed circulating (plasma) markers of endothelial and platelet activation/dysfunction (enzyme-linked immunoassays) in the specific setting of advanced PAH associated with congenital heart disease, during the course of sildenafil and tadalafil therapies. Thirty-one patients were enrolled (age 10-54 years), most of them with chronic hypoxemia and elevated hematocrit. Drugs were administered orally for 6 months (sildenafil {[}n = 16], 20 mg t.i.d.; tadalafil {[}n = 15], single daily dose of 40 mg). Measurements were performed at baseline, and 90 and 180 days. Results Compared to controls, patients had elevated baseline beta-thromboglobulin (beta-TG, P = .002), P-selectin (P = .027), tissue-type plasminogen activator (t-PA, P = .009), and von Willebrand factor antigen (VWF:Ag, P = .010). Thrombomodulin was importantly reduced (TM, P < .001), while soluble CD40 Ligand was not changed (P = .320). Tadalafil administration was associated with improvement of beta-TG (P = .004), t-PA (P = .003) and TM (P = .046) levels, while P-selectin was improved by sildenafil treatment only (P = .034). VWF:Ag improved transiently in the sildenafil group (P = .019). Both therapies were associated with improvement of the physical capacity (functional class and distance walked during the 6-minute test, P < .05), hematocrit and hemoglobin level (P < .05), and health-related quality of life (physical and mental components, P < .05). Conclusion In PAH associated with congenital heart disease, phosphodiesterase 5 inhibitors seem to have beneficial actions at microcirculatory level, beyond the proposed effects as vasodilators. (AU)

• FAPESP's process: 12/10739-0 - Comparative study on the effects of sildenafil and tadalafil in advanced pulmonary arterial hypertension associated with congenital heart defects (Eisenmenger syndrome)
• Grantee: Antonio Augusto Barbosa Lopes
• Support Opportunities: Regular Research Grants