Downstaging in opportunistic breast cancer screening in Brazil: a temporal trend analysis

Author(s)

Vale, Diama Bhadra ^[1] ; Cardoso Filho, Cassio ^[1] ; Shinzato, Julia Yoriko ^[1] ; Spreafico, Fernanda Servidoni ^{[1, 2]} ; Basu, Partha ^[3] ; Zeferino, Luiz Carlos ^[1]

Affiliation

^[1] Univ Estadual Campinas, Obstet & Gynecol Dept, Sch Med Sci, Rua Alexander Fleming 101, BR-13083790 Campinas, SP - Brazil

^[2] Pontificia Univ Catolica Campinas, Med Sch, Av John Boyd Dunlop S-N, BR-13060904 Campinas, SP - Brazil

^[3] Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon - France

• Document type: Journal article
• Source: BMC CANCER; v. 19, MAY 10 2019.
• Web of Science Citations: 1

Abstract

BackgroundBreast cancer is the most common female cancer in Brazil with an estimated 60 thousand new cases per year. Widespread use of mammography opportunistic screening has been observed in the last 20years, including women under 50years old. The present study aimed to analyse the trends in breast cancer stage distribution at diagnosis as a function of age in the study period.MethodsThis paper examined temporal trends of stage distribution in women with breast cancer diagnosed between 2000 and 2015 in SAo Paulo state, Brazil. Data from the Hospital Cancer Registry of the region were utilized. Completeness was high. The sample was described according to age, stage and date of diagnosis using absolute frequency and proportions (%). For trends, the Cochran-Armitage test was used with a 5% level of significance (P-value<0.05).ResultsA total of 93,674 women were included in the analysis with a median age of 56years old. One-third (34.4%) of the women were younger than 50years old, and stage II was the most frequent stage (36.4%), even when analysed by age groups. Stage 0 corresponded to 7.7% (7247 women) of cases. In the study period, there was a significant trend towards an increase in Stages 0, I and IV (P<0.01) and a trend towards a decrease in Stages IIA, IIB and IIIB (P<0.001). Stage IIA was more prevalent until 2009, and stage I was more prevalent thereafter. The trends to increase the proportion of Stages 0 and I and to decrease the proportion of stages IIA, IIB and IIIB were significant in all age groups.ConclusionsBreast cancer cases are diagnosed mainly at early stages, and approximately one-third of cases are younger than 50years old. Downstaging has been shown. Opportunistic screening may have supported these results. Further studies are needed to show whether these results will impact the prognosis. (AU)

• FAPESP's process: 17/21908-1 - Population-based assessment of breast cancer screening, diagnosis and death in the city of Campinas, as a function of age
• Grantee: Diama Bhadra Andrade Peixoto Do Vale
• Support Opportunities: Regular Research Grants