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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Systematic Risk Assessment and Meta-Analysis on the Use of Oral beta-Alanine Supplementation

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Author(s):
Dolan, Eimear [1] ; Swinton, Paul A. [2] ; Painelli, Vitor de Salles [1] ; Hemingway, Benedict Stephens [2] ; Mazzolani, Bruna [1] ; Smaira, Fabiana Infante [1] ; Saunders, Bryan [1] ; Artioli, Guilherme G. [1] ; Gualano, Bruno [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Rheumatol Div, Appl Physiol & Nutr Res Grp, Fac Med, Sao Paulo - Brazil
[2] Robert Gordon Univ, Sch Hlth Sci, Aberdeen - Scotland
Total Affiliations: 2
Document type: Review article
Source: ADVANCES IN NUTRITION; v. 10, n. 3, p. 452-463, MAY 2019.
Web of Science Citations: 1
Abstract

beta-Alanine supplementation is one of the world's most commonly used sports supplements, and its use as a nutritional strategy in other populations is ever-increasing, due to evidence of pleiotropic ergogenic and therapeutic benefits. Despite its widespread use, there is only limited understanding of potential adverse effects. To address this, a systematic risk assessment and meta-analysis was undertaken. Four databases were searched using keywords and Medical Subject Headings. All human and animal studies that investigated an isolated, oral, beta-alanine supplementation strategy were included. Data were extracted according to 5 main outcomes, including 1) side effects reported during longitudinal trials, 2) side effects reported during acute trials, 3) effect of supplementation on circulating health-related biomarkers, 4) effect of supplementation on skeletal muscle taurine and histidine concentration, and 5) outcomes from animal trials. Quality of evidence for outcomes was ascertained using the Grading of Recommendations Assessment Development and Evaluation (GRADE) framework, and all quantitative data were meta-analyzed using multilevel models grounded in Bayesian principles. In total, 101 human and 50 animal studies were included. Paraesthesia was the only reported side effect and had an estimated OR of 8.9 {[}95% credible interval (CrI): 2.2, 32.6] with supplementation relative to placebo. Participants in active treatment groups experienced similar dropout rates to those receiving the placebo treatment. beta-Alanine supplementation caused a small increase in circulating alanine aminotransferase concentration (effect size, ES: 0.274, CrI: 0.04, 0.527), although mean data remained well within clinical reference ranges. Meta-analysis of human data showed no main effect of beta-alanine supplementation on skeletal muscle taurine (ES: 0.156; 95% CrI: -0.38, 0.72) or histidine (ES: -0.15; 95% CrI: -0.64, 0.33) concentration. A main effect of beta-alanine supplementation on taurine concentration was reported for murine models, but only when the daily dose was >= 3% beta-alanine in drinking water. The results of this review indicate that beta-alanine supplementation within the doses used in the available research designs, does not adversely affect those consuming it. (AU)

FAPESP's process: 17/09635-0 - Factors determining the carnosine content of human skeletal muscle: influence of age and sex
Grantee:Eimear Bernadette Dolan
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/11328-2 - Carnosine metabolism in skeletal muscle: a multi-approach study. Substudy 3: exploring carnosine role in skeletal muscle
Grantee:Eimear Bernadette Dolan
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/11948-8 - Life without carnosine: development and characterization of a KO rat model for studying the physiological role of carnosine and its implications to physical exercise and muscle metabolism
Grantee:Guilherme Giannini Artioli
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 13/04806-0 - Effects of 12 weeks of high-intensity intermittent training on intramuscular carnosine concentrations
Grantee:Vitor de Salles Painelli
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 13/14746-4 - Carnosine metabolism in skeletal muscle: a multi-approach study
Grantee:Bruno Gualano
Support type: Research Projects - Thematic Grants
FAPESP's process: 17/04973-4 - Nutritional supplementation and exercise to optimise exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Scholarships in Brazil - Young Researchers