Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise

Author(s)

Pereira Batatinha, Helena Angelica ^[1] ; Diniz, Tiego Aparecido ^[1] ; de Souza Teixeira, Alexandre Abilio ^[1] ; Krueger, Karsten ^[2] ; Rosa-Neto, Jose Cesar ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Cell & Dev Biol, 1524 Prof Lineu Prestes Av, BR-05508000 Sao Paulo, SP - Brazil

^[2] Leibniz Univ Hannover, Inst Sports Sci, Dept Exercise & Hlth, Hannover - Germany

• Document type: Review article
• Source: Journal of Cellular Physiology; v. 234, n. 9, p. 14883-14895, SEP 2019.
• Web of Science Citations: 3

Abstract

Aging is one of the risk factors for the development of low-grade inflammation morbidities, such as several types of cancer and neurodegenerative diseases, due to changes in the metabolism, hormonal secretion, and immunosenescence. The senescence of the immune system leads to improper control of infections and tissue damage increasing age-related diseases. One of the mechanisms that maintain cellular homeostasis is autophagy, a cell-survival mechanism, and it has been proposed as one of the most powerful antiaging therapies. Regular exercise can reestablish autophagy, probably through AMP-activated protein kinase activation, and help in reducing the age-related senescence diseases. Therefore, in this study, we discuss the effects of exercise training in immunosenescence and autophagy, preventing the two main age-related disease, cancer and neurodegeneration. (AU)

• FAPESP's process: 16/10561-8 - Probiotic Supplementation effect on oral microbiota modulation and upper respiratory tract infection in runners
• Grantee: Helena Angélica Pereira Batatinha
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 16/01409-8 - The caracterization of antiinflammatory effect of palmitoleic acid suplemmentation in hepatic inflammation; The role of PPARs.
• Grantee: José Cesar Rosa Neto
• Support Opportunities: Regular Research Grants