| Full text | |
| Author(s): Show less - |
Forti, Rodrigo M.
[1, 2, 3]
;
Favilla, Christopher G.
[4]
;
Cochran, Jeffrey M.
[1]
;
Baker, Wesley B.
[5]
;
Detre, John A.
[4, 6]
;
Kasner, Scott E.
[4]
;
Mullen, Michael T.
[4]
;
Messe, Steven R.
[4]
;
Kofke, W. Andrew
[7]
;
Balu, Ramani
[4]
;
Kung, David
[6, 8]
;
Pukenas, Bryan A.
[6, 8]
;
Sedora-Roman, Neda I.
[6]
;
Hurst, Robert W.
[6, 8]
;
Choudhri, Omar A.
[8]
;
Mesquita, Rickson C.
[2, 3]
;
Yodh, Arjun G.
[1]
Total Authors: 17
|
| Affiliation: | [1] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 - USA
[2] Brazilian Inst Neurosci & Neurotechnol, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Inst Phys, Rua Sergio Buarque de Holanda 777, BR-13083859 Campinas, SP - Brazil
[4] Univ Penn, Dept Neurol, Philadelphia, PA 19104 - USA
[5] Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 - USA
[6] Univ Penn, Dept Radiol, Philadelphia, PA 19104 - USA
[7] Univ Penn, Dept Anesthesiol & Crit Care, Philadelphia, PA 19104 - USA
[8] Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 - USA
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | JOURNAL OF STROKE & CEREBROVASCULAR DISEASES; v. 28, n. 6, p. 1483-1494, JUN 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Introduction: Mechanical thrombectomy is revolutionizing treatment of acute stroke due to large vessel occlusion (LVO). Unfortunately, use of the modified Thrombolysis in Cerebral Infarction score (mTICI) to characterize recanalization of the cerebral vasculature does not address microvascular perfusion of the distal parenchyma, nor provide more than a vascular ``snapshot.{''} Thus, little is known about tissue-level hemodynamic consequences of LVO recanalization. Diffuse correlation spectroscopy (DCS) and diffuse optical spectroscopy (DOS) are promising methods for continuous, noninvasive, contrast-free transcranial monitoring of cerebral microvasculature. Methods: Here, we use a combined DCS/DOS system to monitor frontal lobe hemodynamic changes during endovascular treatment of 2 patients with ischemic stroke due to internal carotid artery (ICA) occlusions. Results and Discussion: The monitoring instrument identified a recanalization-induced increase in ipsilateral cerebral blood flow (CBF) with little or no concurrent change in contralateral CBF and extracerebral blood flow. The results suggest that diffuse optical monitoring is sensitive to intracerebral hemodynamics in patients with ICA occlusion and can measure microvascular responses to mechanical thrombectomy. (AU) | |
| FAPESP's process: | 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology |
| Grantee: | Fernando Cendes |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 16/13139-5 - Development of optical probes and algorithms for neurocritical care monitoring |
| Grantee: | Rodrigo Menezes Forti |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |