Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of antileishmanial activity of harzialactone a isolated from the marine-derived fungus Paecilomyces sp

Full text
Show less -
Braun, Glaucia H. [1, 2] ; Ramos, Henrique P. [1] ; Candido, Ana C. B. B. [1] ; Pedroso, Rita C. N. [1] ; Siqueira, Katia A. [3] ; Soares, Marcos A. [3] ; Dias, Gustavo M. [4] ; Magalhaes, Lizandra G. [1] ; Ambrosio, Sergio R. [1] ; Januario, Ana H. [1] ; Pietro, Rosemeire C. L. R. [2]
Total Authors: 11
[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP - Brazil
[2] UNESP Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Araraquara, SP - Brazil
[3] Univ Fed Mato Grosso, Inst Biociencias, Dept Bot & Ecol, Cuiaba, Mato Grosso - Brazil
[4] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Sao Bernardo Do Campo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: NATURAL PRODUCT RESEARCH; v. 35, n. 10 MAY 2019.
Web of Science Citations: 7

Fractionation of extracts from the culture broth of the marine-derived fungus, Paecilomyces sp. 7A22, resulted in the isolation of the harzialactone A (HA), a known compound previously isolated from fungi of marine environments. The chemical structure of HA was determined by spectroscopic analyses. Upon evaluation of HA on antileishmanial assays against Leishmania amazonensis, HA exhibited significant activity against promastigotes forms with IC50 of 5.25 mu g mL(-1) and moderate activity against intracellular amastigotes with IC50 of 18.18 mu g mL(-1). This is the first report on the antileishmanial activity of HA, and the effects of HA presented in this work suggest that this class of compounds are suitable for future biological in vitro and in vivo studies for the search of natural products with activity against Leishmania spp. Furthermore, the present results corroborate marine-derived fungi as a promising source of natural products with antiparasitic activity. (AU)

FAPESP's process: 17/14261-1 - Investigation of the schistosomicidal, leishmanicidal and cytototoxic potential of fungal lineages associated with marine invertebrates belonging to Ascidiacea
Grantee:Ana Helena Januário
Support type: Regular Research Grants
FAPESP's process: 14/19184-7 - Schistosomicidal potential investigation of marine invertebrates belonging to the Ascidiacea family
Grantee:Ana Helena Januário
Support type: Regular Research Grants