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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Controlling for Artifacts in Widefield Optical Coherence Tomography Angiography Measurements of Non-Perfusion Area

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Author(s):
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De Pretto, Lucas R. [1, 2] ; Moult, Eric M. [1] ; Alibhai, A. Yasin [3] ; Carrasco-Zevallos, Oscar M. [1] ; Chen, Siyu [1] ; Lee, ByungKun [1] ; Witkin, Andre J. [3] ; Baumal, Caroline R. [3] ; Reichel, Elias [3] ; de Freitas, Anderson Zanardi [2] ; Duker, Jay S. [3] ; Waheed, Nadia K. [3] ; Fujimoto, James G. [1]
Total Authors: 13
Affiliation:
[1] MIT, Dept Elect Engn & Comp Sci, Res Lab Elect, 77 Massachusetts Ave, Cambridge, MA 02139 - USA
[2] Nucl & Energy Res Inst, IPEN CNEN SP, Sao Paulo - Brazil
[3] Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 - USA
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 9, JUN 24 2019.
Web of Science Citations: 1
Abstract

The recent clinical adoption of optical coherence tomography (OCT) angiography (OCTA) has enabled non-invasive, volumetric visualization of ocular vasculature at micron-scale resolutions. Initially limited to 3 mm x 3 mm and 6 mm x 6 mm fields-of-view (FOV), commercial OCTA systems now offer 12 mm x 12 mm, or larger, imaging fields. While larger FOVs promise a more complete visualization of retinal disease, they also introduce new challenges to the accurate and reliable interpretation of OCTA data. In particular, because of vignetting, wide-field imaging increases occurrence of low-OCT-signal artifacts, which leads to thresholding and/or segmentation artifacts, complicating OCTA analysis. This study presents theoretical and case-based descriptions of the causes and effects of low-OCT-signal artifacts. Through these descriptions, we demonstrate that OCTA data interpretation can be ambiguous if performed without consulting corresponding OCT data. Furthermore, using wide-field non-perfusion analysis in diabetic retinopathy as a model widefield OCTA usage-case, we show how qualitative and quantitative analysis can be confounded by low-OCT-signal artifacts. Based on these results, we suggest methods and best-practices for preventing and managing low-OCT-signal artifacts, thereby reducing errors in OCTA quantitative analysis of non-perfusion and improving reproducibility. These methods promise to be especially important for longitudinal studies detecting progression and response to therapy. (AU)

FAPESP's process: 16/17342-0 - Application of speckle analysis techniques in OCT for optical diagnosis in vivo
Grantee:Lucas Ramos de Pretto
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 15/15775-3 - Optical Coherence Tomography signal autocorrelation analysis algorithm applied to blood flow monitoring in mice with Metabolic Syndrome
Grantee:Lucas Ramos de Pretto
Support Opportunities: Scholarships in Brazil - Doctorate