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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity

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Souza-Moreira, Tatiana M. [1, 2] ; Severi, Juliana A. [1] ; Rodrigues, Edvanio Ramos [1] ; de Paula, Mayara Ivani [1] ; Freitas, Jolindo A. [1] ; Vilegas, Wagner [2] ; Pietro, Rosemeire C. L. R. [1]
Total Authors: 7
[1] Sao Paulo State Univ UNESP, Dept Drugs & Med, Araraquara - Brazil
[2] Sao Paulo State Univ UNESP, Dept Organ Chem, Araraquara - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NATURAL PRODUCT RESEARCH; v. 33, n. 17, p. 2579-2582, SEP 2 2019.
Web of Science Citations: 5

Plinia cauliflora is a plant species with edible fruits but its chemical composition is not totally known yet although former studies showed its potential as antifungal agent. This work aimed the chemical analysis of the leaves, the activity against fungi species and evaluated cytotoxicity. Extract was obtained with 70% ethanol. An ethyl acetate fraction was obtained and glycosylated quercetin and myricetin were isolated. Samples were tested against Candida species, dermatophytes and entomopathogenic fungi. Cytotoxicity was evaluated against fibroblast cells. Extract showed good activity against C. albicans (minimum inhibitory concentration at 156 mu g/mL), C. parapsilosis (78 mu g/mL), C. krusei (19 mu g/mL), Trichophyton rubrum (78 mu g/mL) and Microsporum canis (156 mu g/mL). Isolated compounds were more active against C. krusei and T. rubrum. The extract, which was the more active sample, demonstrated low cytotoxic effect and encourage more studies against rising non-albicans species and dermatophyte T. rubrum. (AU)

FAPESP's process: 08/00039-6 - Study of chemical composition and antifungal activity of Plinia cauliflora (Mart.) Kausel (Myrtaceae)
Grantee:Rosemeire Cristina Linhari Rodrigues Pietro
Support Opportunities: Regular Research Grants