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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Reduced Graphene Oxide Decorated with AuNPs as a New Aptamer-Based Biosensor for the Detection of Androgen Receptor from Prostate Cells

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Crulhas, Bruno P. [1] ; Basso, Caroline R. [1] ; Parra, Joao P. R. L. L. [1] ; Castro, Gustavo R. [1] ; Pedrosa, Valber A. [1]
Total Authors: 5
[1] UNESP, Dept Chem & Biochem, Inst Biosci, Botucatu, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Web of Science Citations: 1

Here we described an aptasensor based on graphene oxide (GO) decorated with gold nanoparticles (AuNPs) able to detect the AR released by prostate cells, in order to provide new insights about the relationship between AR and prostate cancer for a more precise diagnosis for cancer. Characterization of the surface modified GE was carried out by cyclic voltammetry and electrochemical impedance spectroscopy using ferrocene as a redox probe. Under the optimized experimental conditions, a detection limit of 0.5 ng/mL (3 sigma/slope) was obtained by the present electrochemical biosensor, along with a linear range of 0-110 ng/mL. By virtue of excellent sensitivity, specificity, and repeatability, the present electrochemical biosensor provides a potential application in clinical diagnosis. (AU)

FAPESP's process: 16/15919-8 - Monitoring of prostate cancer biomarkers using a biosensor
Grantee:Valber de Albuquerque Pedrosa
Support type: Regular Research Grants
FAPESP's process: 16/25749-2 - Study of prostate cancer biomarkers by aptameric sensors
Grantee:Bruno Pereira Crulhas
Support type: Scholarships in Brazil - Post-Doctorate