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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation

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Oliveira-Santos, Alecia A. [1] ; Salvatori, Roberto [2] ; Nogueira, Monica C. [3] ; Bueno, Ana C. [3] ; Barros-Oliveira, Cynthia S. [1] ; Leal, Angela C. G. B. [1] ; Marinho, Cindi G. [1] ; Damascena, Nayra P. [1] ; Oliveira, Djane A. [1] ; Melo, Manuela A. [1] ; Oliveira, Carla R. P. [1] ; da Costa, Flavia O. [1] ; dos Santos, Jessica S. S. [1] ; Santos, Paula F. C. [1] ; Campos, Viviane C. [1] ; Santos, Elenilde G. [1] ; Melo, Enaldo V. [1] ; Barbosa, Meirielly L. A. [1] ; Rocha, Ivina E. S. [1] ; de Castro, Margaret [3] ; Aguiar-Oliveira, Manuel H. [1]
Total Authors: 21
[1] Univ Fed Sergipe, Div Endocrinol, BR-49060100 Aracaju, Sergipe - Brazil
[2] Johns Hopkins Univ, Sch Med, Div Endocrinol & Metab, Baltimore, MD 21287 - USA
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM; v. 104, n. 7, p. 2777-2784, JUL 2019.
Web of Science Citations: 0

Context: GH and IGF-1 are crucial for attainment of normal body size and regulation of food intake, nutrient storage, and insulin sensitivity. Enteroendocrine connections exist between the GH IGF-1 axis and insulin, ghrelin, and glucagon-like peptide 1 (GLP-1). The status of these connections in GH deficiency (GHD) is unknown. Objective: To study the enteroendocrine connections before and after a standard meal test in a homogeneous population of adults with congenital untreated isolated GHD (IGHD) due to a mutation in the GHRH receptor gene. Design: In a cross-sectional study of 20 individuals with IGHD and 20 control subjects, we measured glucose, insulin, ghrelin, and GLP-1 before and 30, 60, 120, and 180 minutes after a standardized test meal. Homeostasis model assessment index of insulin resistance (HOMA-IR) and homeostasis model assessment (HOMA)-6 were calculated. Participants scored feelings of hunger, fullness, and prospective food consumption on a visual analog scale. Main Outcome Measures: Area under the curve (AUC) values of glucose, insulin, ghrelin, GLP-1, hunger, fullness, and prospective food consumption. Results: Fasting HOMA-IR and HOMA-6 were lower in individuals with IGHD than in control subjects (P = 0.002 and P = 0.023, respectively). AUC was higher for hunger (P < 0.0001), glucose (P = 0.0157), ghrelin (P < 0.0001), and GLP-1 (P < 0.0001) and smaller for fullness (P < 0.0001) in individuals with IGHD compared with control subjects. There was no difference in AUC for prospective food consumption or insulin. Conclusions: Untreated IGHD is associated with increased GLP-1 secretion and reduced postprandial ghrelin and hunger attenuation in response to a mixed meal. These enteroendocrine connections can result in a favorable outcome in terms of environmental adaptation and guaranteeing appropriate food intake and can confer metabolic benefits. (AU)

FAPESP's process: 14/03989-6 - Uncovering pathophysiological and molecular mechanisms involved in tumorigenesis by platforms for next-generation sequencing (NGS)
Grantee:Margaret de Castro
Support type: Research Projects - Thematic Grants