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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Maternal Low-Protein Diet Impairs Prostate Growth in Young Rat Offspring and Induces Prostate Carcinogenesis With Aging

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Author(s):
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Santos, Sergio A. A. [1] ; Camargo, Ana C. [1] ; Constantino, Flavia B. [1] ; Colombelli, Ketlin T. [1] ; Mani, Fernanda [2] ; Rinaldi, Jaqueline C. [1] ; Franco, Suelen [1] ; Portela, Luiz M. F. [1] ; Duran, Bruno O. S. [1] ; Scarano, Wellerson R. [1] ; Hinton, Barry T. [3] ; Felisbino, Sergio L. [1] ; Justulin, Luis A. [1]
Total Authors: 13
Affiliation:
[1] UNESP, Inst Biosci, Dept Morphol, Botucatu, SP - Brazil
[2] UNESP, Inst Biosci, Dept Chem & Biochem, Botucatu, SP - Brazil
[3] Univ Virginia Hlth Syst, Dept Cell Biol, Charlottesville, VA - USA
Total Affiliations: 3
Document type: Journal article
Source: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES; v. 74, n. 6, p. 751-759, JUN 2019.
Web of Science Citations: 2
Abstract

Carcinogenesis is frequently linked to genetic background, however, exposure to environmental risk factors has gained attention as the etiologic agent for several types of cancer, including prostate. The intrauterine microenvironment has been described as a preponderant factor for offspring health; and maternal exposure to insult has been linked to chronic disease in older offspring. Using a model of maternal exposure to low-protein diet (LPD; 6% protein), we demonstrated that impairment of offspring rat prostatic growth on postnatal day (PND) 21 was associated with prostate carcinogenesis in older offspring (PND 540). One explanation is that maternal LPD consumption exposed offspring to an estrogenic intrauterine microenvironment, which potentially sensitized prostate cells early during glandular morphogenesis, increasing cellular response to estrogen in older rats. The onset of accelerated prostatic growth, observed on PND 21, associated with an unbalanced estrogen/testosterone ratio and increased circulating IGF-1 in older offspring appears to contribute to the development of prostate carcinoma in groups on gestational low protein and gestational and lactational low protein diets (33 and 50%, respectively). Our study strongly indicated maternal exposure to LPD as a potential risk factor for induction of slow-growing prostate carcinogenesis in rat offspring later in life. (AU)

FAPESP's process: 14/08531-8 - Impact of protein restriction during pregnancy and lactation on rat prostate: relation between the signaling pathway of Insulin/IGF, development and aging
Grantee:Sérgio Alexandre Alcantara dos Santos
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/01063-7 - Integrative global analyzes of the rat ventral prostate submitted to maternal protein restriction and its repercussions with aging
Grantee:Luis Antonio Justulin Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 13/24230-5 - Impact of intrauterine fetal programming by low protein diet on rat prostate stem cells and morphogenesis
Grantee:Luis Antonio Justulin Junior
Support Opportunities: Regular Research Grants