Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice

Author(s)

Toricelli, Mariana ^{[1, 2]} ; Evangelista, Sebastiana Ribeiro ^{[1, 2]} ; Oliveira, Larissa Rolim ^[2] ; Viel, Tania Araujo ^{[3, 1]} ; Buck, Hudson Sousa ^{[1, 2]}

Affiliation

^[1] Res Grp Neuropharmacol Aging ReGNA, Sao Paulo - Brazil

^[2] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo - Brazil

• Document type: Journal article
• Source: FRONTIERS IN AGING NEUROSCIENCE; v. 11, JUL 12 2019.
• Web of Science Citations: 0

Abstract

Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) in neurodegeneration and this system has been associated with inflammation and immunogenic responses in the central and peripheral systems by the activation of the B1 and B2 receptors. Previous work by our group showed that bradykinin (BK) and the B2 receptor played a possible role in neuroprotection. Therefore, the objective of this study was to evaluate the participation of B2 receptors in cell viability, neuroinflammatory response and neuroplasticity in organotypic hippocampal cultures (OHCs) of 6- and 12-month-old mice. It was observed that activation of the B2 receptor by bradykinin decreased the inflammatory response and increased plasticity in 12-month-old slices. Conversely, there was an increase in the inflammatory response and a decrease in neural plasticity in the 6-month-old slices. In both ages, an increase in cell viability was observed. This data suggests that the function of the kinin B2 receptor in the hippocampus is modulated by age, providing neuroprotective action in old age. (AU)

• FAPESP's process: 13/13656-1 - Study of the neuroprotective role of kinin B2 receptor in the Alzheimer's Disease
• Grantee: Hudson de Sousa Buck
• Support type: Regular Research Grants
• FAPESP's process: 17/21655-6 - Study of the cell survival modulation by B2 receptor for bradykinin and its impact on neuroinflamation in organotypic hippocampal culture of transgenic mice for Alzheimer's disease.
• Grantee: Mariana Toricelli Pinto
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 16/07115-6 - Translational study of strategies and biomarkers to promote healthspan
• Grantee: Tânia Araújo Viel
• Support type: Regular Research Grants