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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hierarchical Self-Assembly of Peptides and its Applications in Bionanotechnology

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Gerbelli, Barbara B. [1] ; Vassiliades, Sandra V. [1] ; Rojas, Jose E. U. [1] ; Pelin, Juliane N. B. D. [1] ; Mancini, Rodrigo S. N. [1] ; Pereira, Wallace S. G. [1] ; Aguilar, Andrea M. [2] ; Venanzi, Mariano [3] ; Cavalieri, Francesca [3, 4] ; Giuntini, Francesca [5] ; Alves, Wendel A. [1]
Total Authors: 11
[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre - Brazil
[2] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema - Brazil
[3] Univ Roma Tor Vergata, Dept Chem Sci & Technol, Via Cracovia 50, I-00133 Rome, RM - Italy
[4] Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010 - Australia
[5] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Byrom St, Liverpool L3 3AF, Merseyside - England
Total Affiliations: 5
Document type: Journal article
Web of Science Citations: 1

Self-assembled structures obtained from organic molecules have shown great potential for applications in a wide range of domains. In this context, short peptides prove to be a particularly versatile class of organic building blocks for self-assembled materials. These species afford the biocompatibility and polymorphic richness typical of proteins while allowing synthetic availability and robustness typical of smaller molecules. At the nano-to-mesoscale, the architectures obtained from peptide units exhibit stability and a large variety of morphologies, the most common of which are nanotubes, nanoribbons, and nanowires. This review describes the formation of peptide-based self-assembled structures triggered by different stimuli (e.g., ionic strength, pH, and polarity), and the interactions that drive the assembling processes. It is surveyed how judicious molecular design is exploited to impart favourable assembling properties to afford systems with desired characteristics. A large body of literature provides the experimental and in silico data to predict self-assembly in a given peptide system and obtain different supramolecular organizations for applications in a wide range of fields, from transport to sensing, from catalysis to drug delivery and tissue regeneration. (AU)

FAPESP's process: 18/05888-3 - Biosensors based on amphiphilic peptides for detection and diagnosis of diseases
Grantee:Barbara Bianca Gerbelli
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/50188-4 - Fabrication and characterization of peptide-polymer hybrid hydrogels for bioanalytical applications
Grantee:Wendel Andrade Alves
Support Opportunities: Regular Research Grants
FAPESP's process: 17/02317-2 - Interfaces in materials: electronic, magnetic, structural and transport properties
Grantee:Adalberto Fazzio
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/50972-1 - Francesca Giuntini | Liverpool John Moores University - Inglaterra
Grantee:Wendel Andrade Alves
Support Opportunities: Research Grants - Visiting Researcher Grant - International
FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
Grantee:Lauro Tatsuo Kubota
Support Opportunities: Research Projects - Thematic Grants