Nanostructured lipid carriers loaded with free phytosterols for food applications

Author(s)

Santos, Valeria da Silva ^[1] ; Braz, Bruno Brito ^[1] ; Silva, Alan Avila ^[2] ; Cardoso, Lisandro Pavie ^[3] ; Badan Ribeiro, Ana Paula ^[2] ; Andrade Santana, Maria Helena ^[1]

Affiliation

^[1] Univ Estadual Campinas, Sch Chem Engn, Dept Biotechnol Proc, 500 Albert Einstein Ave, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Food Engn, Dept Food Technol, 80 Monteiro Lobato St, BR-13083970 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Inst Phys Gleb Wataghin, Dept Appl Phys, 777 Sergio Buarque de Holanda St, BR-13083859 Campinas, SP - Brazil

• Document type: Journal article
• Source: Food Chemistry; v. 298, NOV 15 2019.
• Web of Science Citations: 0

Abstract

The objective of this study was to develop nanostructured lipid carriers (NLCs) with free phytosterols (FP) using conventional fats and oils. Lipid matrices (LMs) and NLCs were produced with high oleic sunflower oil, fully hydrogenated canola (CA) and crambe (CR) oils by high-pressure homogenization (HPH). The NLCs were evaluated for hydrodynamic diameter (Z-ave), polydispersity index (PDI), and zeta potential (ZP). The melting behavior and polymorphism were investigated for both, the LMs and NLCs. The NLCs presented particle sizes ranging from 148.23 to 342.10 nm, PDI from 0.275 to 0.481, and ZP between -22.27 and -29.70 mV. The NLCs presented higher thermal resistance than that of the LMs. The use of CA and CR separately in the NLC formulations favored the incorporation of FP. The LMs and NLCs presented crystals in beta-form and in mixtures of beta' and beta forms. The developed NLCs can be used for food enrichment, such as spreads, margarine, and beverages. (AU)

• FAPESP's process: 16/11261-8 - OILS, FATS AND NANOTECHNOLOGY:DEVELOPMENT OF SOLID LIPID NANOPARTICLES AND NANOSTRUCTURED LIPID CARRIERS FOR INCORPORTATION OF BIOACTIVE LIPOPHILIC COMPOUNDS
• Grantee: Ana Paula Badan Ribeiro
• Support Opportunities: Regular Research Grants