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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders

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Author(s):
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Tahira, Ana Carolina [1] ; Barbosa, Andre Rocha [2, 1] ; Feltrin, Arthur Sant'Anna [3] ; Gastaldi, Vinicius Daguano [1] ; Calegari de Toledo, Victor Hugo [1] ; de Carvalho Pereira, Jose Geraldo [4] ; Garcia Lisboa, Bianca Cristina [1] ; de Souza Reis, Viviane Neri [1] ; Feio dos Santos, Ana Cecilia [1, 5] ; Maschietto, Mariana [4] ; Brentani, Helena [2, 6, 7, 1, 8]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Inst Psiquiatria, Fac Med, LIM23, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Interinst Grad Program Bioinformat, Sao Paulo, SP - Brazil
[3] Fed Univ ABC, Ctr Math Comp & Cognit, Santo Andre, SP - Brazil
[4] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, Campinas, SP - Brazil
[5] Inst Evandro Chagas SVS MS, Secao Parasitol, Lab Pesquisas Basicas Malaria Entomol, Ananindeua, PA - Brazil
[6] Natl Inst Dev Psychiat Children & Adolescents INP, Sao Paulo, SP - Brazil
[7] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo, SP - Brazil
[8] Univ Sao Paulo, Hosp Clin HCFMUSP, Inst Psiquiatria, Fac Med, Sao Paulo, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Source: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS; v. 180, n. 6, SI, p. 390-414, SEP 2019.
Web of Science Citations: 1
Abstract

The male-biased prevalence of certain neurodevelopmental disorders and the sex-biased outcomes associated with stress exposure during gestation have been previously described. Here, we hypothesized that genes distinctively targeted by only one or both homologous proteins highly conserved across therian mammals, SOX3 and SRY, could induce sexual adaptive changes that result in a differential risk for neurodevelopmental disorders. ChIP-seq/chip data showed that SOX3/SRY gene targets were expressed in different brain cell types in mice. We used orthologous human genes in rodent genomes to extend the number of SOX3/SRY set (1,721). These genes were later found to be enriched in five modules of coexpressed genes during the early and mid-gestation periods (FDR < 0.05), independent of sexual hormones. Genes with differential expression (24, p < 0.0001) and methylation (40, p < 0.047) between sexes were overrepresented in this set. Exclusive SOX3 or SRY target genes were more associated with the late gestational and postnatal periods. Using autism as a model sex-biased disorder, the SOX3/SRY set was enriched in autism gene databases (FDR <= 0.05), and there were more de novo variations from the male autism spectrum disorder (ASD) samples under the SRY peaks compared to the random peaks (p < 0.024). The comparison of coexpressed networks of SOX3/SRY target genes between male autism and control samples revealed low preservation in gene modules related to stress response (99 genes) and neurogenesis (78 genes). This study provides evidence that while SOX3 is a regulatory mechanism for both sexes, the male-exclusive SRY also plays a role in gene regulation, suggesting a potential mechanism for sex bias in ASD. (AU)

FAPESP's process: 11/14658-2 - Copy number variation in genome of patients with obsessive-compulsive disorder and autism spectrum disorder with restricted interests and repetitive behaviors
Grantee:Helena Paula Brentani
Support type: Regular Research Grants
FAPESP's process: 14/10488-3 - Comparison of methods for prioritization of genes associated to neurodevelopment disorders
Grantee:Arthur Sant'Anna Feltrin
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/06281-7 - CHARACTERIZATION OF THE EPIGENETIC REGULATION IN HUMAN SOLID PAEDIATRIC TUMOURS
Grantee:Mariana Camargo Maschietto
Support type: Scholarships in Brazil - Young Researchers
FAPESP's process: 14/00591-1 - Studies of co-expression gene networks of the orbitofrontal cortex and striatum (postmortem study) of patients with OCD and controls
Grantee:Bianca Cristina Garcia Lisboa
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/00041-1 - Co-expression study among Y chromosome genes and autosomal genes and its relation to Autism Spectrum Disorders (ASD)
Grantee:Ana Carolina Tahira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/04956-6 - Copy Number Variation in Verbal and Non-verbal patients with Autism Spectrum Disorders
Grantee:Viviane Neri de Souza Reis
Support type: Scholarships in Brazil - Master