| Full text | |
| Author(s): |
Total Authors: 2
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| Affiliation: | [1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP - Brazil
[2] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 XZ Nijmegen - Netherlands
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | ANTIOXIDANTS; v. 8, n. 7 JUL 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Betalains are water-soluble natural pigments of increasing importance as antioxidants for pharmaceutical use. Although non-phenolic betalains have lower capacity to scavenge radicals compared to their phenolic analogues, both classes perform well as antioxidants and anti-inflammatory agents in vivo. Here we show that meta-hydroxyphenyl betalain (m-OH-pBeet) and phenylbetalain (pBeet) show higher radical scavenging capacity compared to their N-methyl iminium analogues, in which proton-coupled electron transfer (PCET) from the imine nitrogen atom is precluded. The 1,7-diazaheptamethinium system was found to be essential for the high radical scavenging capacity of betalains and concerted PCET is the most thermodynamically favorable pathway for their one-electron oxidation. The results provide useful insights for the design of nature-derived redox mediators based on the betalain scaffold. (AU) | |
| FAPESP's process: | 13/24964-9 - Study of the antiradical mechanism of betalains. |
| Grantee: | Karina Kinuyo Nakashima |
| Support type: | Scholarships in Brazil - Master |
| FAPESP's process: | 14/22136-4 - Use of green solvents and their mixtures for optimizing chemical processes |
| Grantee: | Omar Abou El Seoud |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/21445-9 - Betalains: structure-property relationships |
| Grantee: | Erick Leite Bastos |
| Support type: | Regular Research Grants |
| FAPESP's process: | 19/06391-8 - Photophysical characterization and anti-inflammatory potential of betalains |
| Grantee: | Erick Leite Bastos |
| Support type: | Regular Research Grants |