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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Rationale on the High Radical Scavenging Capacity of Betalains

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Nakashima, Karina K. [1, 2] ; Bastos, Erick L. [1]
Total Authors: 2
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP - Brazil
[2] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 XZ Nijmegen - Netherlands
Total Affiliations: 2
Document type: Journal article
Source: ANTIOXIDANTS; v. 8, n. 7 JUL 2019.
Web of Science Citations: 0

Betalains are water-soluble natural pigments of increasing importance as antioxidants for pharmaceutical use. Although non-phenolic betalains have lower capacity to scavenge radicals compared to their phenolic analogues, both classes perform well as antioxidants and anti-inflammatory agents in vivo. Here we show that meta-hydroxyphenyl betalain (m-OH-pBeet) and phenylbetalain (pBeet) show higher radical scavenging capacity compared to their N-methyl iminium analogues, in which proton-coupled electron transfer (PCET) from the imine nitrogen atom is precluded. The 1,7-diazaheptamethinium system was found to be essential for the high radical scavenging capacity of betalains and concerted PCET is the most thermodynamically favorable pathway for their one-electron oxidation. The results provide useful insights for the design of nature-derived redox mediators based on the betalain scaffold. (AU)

FAPESP's process: 13/24964-9 - Study of the antiradical mechanism of betalains.
Grantee:Karina Kinuyo Nakashima
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/22136-4 - Use of green solvents and their mixtures for optimizing chemical processes
Grantee:Omar Abou El Seoud
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/21445-9 - Betalains: structure-property relationships
Grantee:Erick Leite Bastos
Support type: Regular Research Grants
FAPESP's process: 19/06391-8 - Photophysical characterization and anti-inflammatory potential of betalains
Grantee:Erick Leite Bastos
Support type: Regular Research Grants