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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dissolution, bioactivity behavior, and cytotoxicity of rare earth-containing bioactive glasses (RE = Gd, Yb)

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Zambanini, Telma [1] ; Borges, Roger [1] ; Faria, Pamela C. [1] ; Delpino, Giulia P. [1] ; Pereira, Isis S. [1] ; Marques, Marcia M. [2] ; Marchi, Juliana [1]
Total Authors: 7
[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre - Brazil
[2] Univ Sao Paulo, Fac Odontol, Dept Dent, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: International Journal of Applied Ceramic Technology; v. 16, n. 5, SI, p. 2028-2039, SEP 2019.
Web of Science Citations: 0

Rare earth-containing bioactive glasses (RE-BGs) have been poorly explored in the biomaterials field, although RE has optical, nuclear, and magnetic properties that could be used in different biomedical applications. In order to verify whether these glasses can be promising as biomaterials, we studied the dissolution, bioactivity, and cytotoxicity of RE-BGs based on the SiO2-Na2O-CaO-P2O5-RE2O3 (RE = Gd, Yb) system. The glasses were obtained by melting-quenching and their particle size was determined by laser diffraction. Their dissolution behavior was studied in Tris-HCl, while bioactivity was performed in simulated body fluid solution under physiological conditions during several periods. The cytotoxicity test was performed using glass-derived conditioned medium and mesenchymal stem cell derived from deciduous teeth. The dissolution results showed that the glasses dissolved under two different kinetics, which are lower for rare earth-containing glasses, due to the more covalent character of Si-O-RE bonds. The bioactivity results evidenced that all glasses showed bioactivity after 24 hours. However, gadolinium and ytterbium promoted a more calcium phosphate deposition, which contrasts with the slower dissolution kinetics of rare earth-containing glasses. All the glasses were considered biocompatible, showing cell viability higher than 80%. The overall results showed that RE-BGs are promising materials for applications that require bioactivity and/or biocompatibility. (AU)

FAPESP's process: 17/18753-6 - Dissolution analysis and in vitro biological characterization of SiO2-CaO-P2O5 system bioglasses doped with holmium
Grantee:Giulia Piagentini Delpino
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/16512-9 - Development of a hydrogel-based delivery system for release of biocompatible glasses ions and drug as support in treatment of bone cancer and subsequent bone regeneration
Grantee:Juliana Marchi
Support type: Regular Research Grants
FAPESP's process: 11/19924-2 - Study and development of advanced novel materials: electronic, magnetic and nanostructured: an interdisciplinary approach
Grantee:Carlos Rettori
Support type: Research Projects - Thematic Grants