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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biopharmaceutical and antifungal properties of ellagic acid-cyclodextrin using an in vitro model of invasive candidiasis

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Author(s):
Gontijo, Aline V. L. [1, 2, 3] ; Sampaio, Aline da G. [2, 3] ; Koga-Ito, Cristiane Y. [2, 3] ; Salvador, Marcos J. [1]
Total Authors: 4
Affiliation:
[1] Univ Campinas UNICAMP, Inst Biol, Dept Plant Biol, Campinas, SP - Brazil
[2] Sao Paulo State Univ UNESP, Dept Environm Engn, Sao Paulo, SP - Brazil
[3] Sao Paulo State Univ UNESP, Oral Biopathol Grad Program, Sao Jose Campos Inst Sci & Technol, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FUTURE MICROBIOLOGY; v. 14, n. 11, p. 957-967, JUL 2019.
Web of Science Citations: 0
Abstract

Aim: To investigate biopharmaceutical and antifungal properties of pure and complexed ellagic acid. Materials \& methods: Caco-2 cells cultured in a Transwell (R) inserts were infected with Candida albicans to develop an in vitro model. Ellagic acid was complexed with cyclodextrins. Microbial compositions, ellagic acid concentration as function of time and characterization studies of complexes were evaluated. Results: Ellagic acid presented ability to reduce C. albicans invasion, although this was not statistically significant. Its poor water solubility and absorption probably limited this ability. Water solubility was increased after complexation with hydroxypropyl-beta-CD; however, ellagic acid/hydroxypropyl-beta-CD did not improve the antifungal activity. Conclusion: Although ellagic acid presented a promising antifungal activity, its biopharmaceutical properties limit such activity and should be improved. (AU)

FAPESP's process: 16/07196-6 - Prospection of innovative therapeutic alternatives for infectious diseases with relevance in Dentistry: low temperature atmospheric pressure plasma and nanoencapsulate of bioactive substance
Grantee:CRISTIANE YUMI KOGA ITO
Support type: Regular Research Grants
FAPESP's process: 16/21207-0 - Evaluation of application potential of ellagic acid nanoencapsuled in cyclodextrin for the treatment of oral candidosis
Grantee:Aline da Graça Sampaio
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/09666-4 - DEPLOYMENT OF ASSAYS FOR EVALUATION OF BIOPHARMACEUTIC CHARACTERISTICS AND BIOACTIVITY OF COMPOUNDS AND BIOACTIVE PRODUCTS USING IN VITRO MODELS OF INVASIVE CANDIDIASIS
Grantee:Aline Vidal Lacerda Gontijo
Support type: Scholarships in Brazil - Post-Doctorate