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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Low-intensity aerobic exercise improves cardiac remodelling of adult spontaneously hypertensive rats

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Author(s):
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Pagan, Luana U. [1] ; Damatto, Ricardo L. [2] ; Gomes, Mariana J. [1] ; Lima, Aline R. R. [1] ; Cezar, Marcelo D. M. [2] ; Damatto, Felipe C. [1] ; Reyes, David R. A. [1] ; Caldonazo, Tulio M. M. [1] ; Polegato, Bertha F. [1] ; Okoshi, Marina P. [1] ; Okoshi, Katashi [1]
Total Authors: 11
Affiliation:
[1] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Botucatu, SP - Brazil
[2] FAIT, Itapeva Social & Agrarian Sci Coll, Ltapeva - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE; v. 23, n. 9 JULY 2019.
Web of Science Citations: 0
Abstract

We evaluated the influence of aerobic training on cardiac remodeling in untreated spontaneously hypertensive rats (SHR). Four experimental groups were used: sedentary (W-SED, n=27) and trained (WEX, n=31) normotensive Wistar rats, and sedentary (SHR-SED, n=27) and exercised (SHR-EX, n=32) hypertensive rats. At 13 months old, trained groups underwent treadmill exercise five days a week for four months. Statistical analysis: ANOVA or Kruskal-Wallis. Exercised groups had higher physical capacity. Hypertensive groups presented left ventricular (LV) concentric hypertrophy with impaired function. Left atrium diameter, LV posterior wall thickness and relative thickness, and isovolumetric relaxation time were lower in SHR-EX than SHR-SED. Interstitial collagen fraction and Type I-Type III collagen ratio were higher in SHR-SED than W-SED. In SHR-EX these parameters had intermediate values between W-EX and SHRSED with no differences between either group. Myocardial matrix metalloproteinase-2 activity, evaluated by zymography, was higher in SHR-SED than W-SED and SHR-EX. TIMP-2 was higher in hypertensive than normotensive groups. In conclusion, low intensity aerobic exercise reduces left atrium dimension and LV posterior wall thickness, and improves functional capacity, diastolic function, and metalloproteinase-2 activity in adult SHR. (AU)

FAPESP's process: 14/00747-1 - Influence of physical exercise on cardiac remodeling, oxidative stress, MAPK and NF-kB pathways signaling in spontaneously hypertensive rats
Grantee:Luana Urbano Pagan
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/17539-5 - Influence of physical exercise on cardiac remodeling, oxidative stress, and signaling of MAPK and NF-kB in spontaneously hypertensive rats
Grantee:Katashi Okoshi
Support Opportunities: Regular Research Grants