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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

RECENT ADVANCES IN COMBINATORIAL BIOSYNTHESIS OF POLYKETIDES: PERSPECTIVES AND CHALLENGES

Full text
Author(s):
Bruno S. Paulo ; Renata Sigrist ; Luciana G. de Oliveira
Total Authors: 3
Document type: Journal article
Source: Química Nova; v. 42, n. 1, p. 71-83, Jan. 2019.
Abstract

Natural products continue to inspire scientists on the search for biological active structures. Recent advances in synthetic biology allow modifying genes to extend structural diversity present on natural products by changing important functional groups guided through genetic information. In this context, polyketides synthases (PKS) represent a class of enzymes from where the first applications and well succeed modifications were achieved. During the last two decades PKSs have been extensively studied, sequenced and deposited in data banks available to scientific community around the world. This newly wide information associated to different methodologies accessible to modify the PKSs genetic circuits including genetic insertion, gene deletion and gene replacement leads to discovery of new natural products. In this review, the recent advances in combinatorial biosynthesis, as well as modern techniques in synthetic biology to promote structural diversity on natural products will be discussed. (AU)

FAPESP's process: 13/12598-8 - Mining a of t1PKS-transAT PKS-NRPS in Streptomyces sp.
Grantee:Renata Sigrist
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/01013-4 - Mining a t1PKS-transAT PKS-NRPS in Streptomyces sp. genome
Grantee:Renata Sigrist
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
Grantee:Arlene Gonçalves Corrêa
Support type: Research Grants - Research Centers in Engineering Program
FAPESP's process: 14/12727-5 - Genome mining in Streptomyces
Grantee:Luciana Gonzaga de Oliveira
Support type: Regular Research Grants