Hyaluronic acid concentration in postmenopausal facial skin after topical estradiol and genistein treatment: a double-blind, randomized clinical trial of efficacy

Author(s)

Patriarca, Marisa Teresinha ^[1] ; Barbosa de Moraes, Andrea Regina ^[1] ; Nader, Helena B. ^[2] ; Petri, Valeria ^[3] ; Maciel Martins, Joao Roberto ^{[2, 4]} ; Teixeira Gomes, Regina Celia ^[5] ; Soares, Jr., Jose Maria ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Gynecol, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Escola Paulista Med, Div Mol Biol, Dept Biochem, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Escola Paulista Med, Dept Dermatol, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Escola Paulista Med, Dept Internal Med, Div Endocrinol, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Escola Paulista Med, Dept Morphol & Genet, Sao Paulo - Brazil

• Document type: Journal article
• Source: MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY; v. 20, n. 3, p. 336-341, MAR 2013.
• Web of Science Citations: 12

Abstract

Objective: The aim of this work was to compare the effects of estradiol and genistein treatment on hyaluronic acid (HA) concentration in postmenopausal facial skin. Methods: In this study, 30 postmenopausal women were evaluated in a prospective, randomized, double-blind trial. The volunteers were postmenopausal women treated in the Gynecology Department of the Federal University of Sao Paulo. The participants were divided into two groups: group E, treated with 0.01% 17 beta-estradiol gel (n = 15), and group G, treated with 4% genistein gel (isoflavones, n = 15). The treatment lasted for 24 consecutive weeks. Preauricular skin biopsies were performed for each participant at baseline (E1 and G1) and after treatment (E2 and G2) to evaluate HA concentration in tissue. The materials were processed using immunohistochemical and biochemical methods. Results: After 24 weeks of treatment, HA concentration increased in both groups, but the effect was greater for estradiol treatment than for genistein treatment. Conclusions: Our data suggest that both treatments may enhance HA concentration in postmenopausal skin but that estrogen produces results that are greater than those produced by isoflavones. (AU)

• FAPESP's process: 11/12417-8 - Gene expression of small leucine-rich proteoglycans (SLRPS), decidual prolactin and growth factors involved in decidualization of the endometrium of female mice with pseudoprenhez with hyperprolactinemia induced by metoclopramide
• Grantee: Regina Célia Teixeira Gomes
• Support Opportunities: Scholarships in Brazil - Post-Doctorate