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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Extracellular vesicles and its advances in female reproduction

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Author(s):
Cavalcante Mendes de Avila, Ana Clara Faquineli [1] ; Andrade, Gabriella Mamede [1] ; Bridi, Alessandra [1] ; Gimenes, Lindsay Unno [2] ; Meirelles, Flavio Vieira [1] ; Perecin, Felipe [1] ; da Silveira, Juliano Coelho [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, Pirassununga, SP - Brazil
[2] Sao Paulo State Univ Unesp, Sch Agr & Vet Sci, Dept Prevent Vet Med & Anim Reprod, Jaboticabal, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ANIMAL REPRODUCTION; v. 16, n. 1, p. 31-38, JAN-MAR 2019.
Web of Science Citations: 1
Abstract

Intercellular communication is an essential mechanism for development and maintenance of multicellular organisms. Extracellular vesicles (EVs) were recently described as new players in the intercellular communication. EVs are double-membrane vesicles secreted by cells and are classified according to their biosynthesis, protein markers and morphology. These extracellular vesicles contain bioactive materials such as miRNA, mRNA, protein and lipids. These characteristics permit their involvement in different biological processes. Reproductive physiology is complex and involves constant communication between cells. Different laboratories have described the presence of EVs secreted by ovarian follicular cells, oviductal cells, in vitro produced embryos and by the endometrium, suggesting that EVs are involved in the development of gametes and embryos, in animals and humans. Therefore, is important to understand physiological mechanisms and contributions of EVs in female reproduction in order to develop new tools to improve in vivo reproductive events and assisted reproductive techniques (ARTs). This review will provide the current knowledge related to EVs in female reproductive tissues and their role in ARTs. (AU)

FAPESP's process: 18/01431-9 - PI3K-Akt signaling pathway effect in oocyte maturation and early embryo development in cattle
Grantee:Gabriella Mamede Andrade
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/02037-0 - Description of a new mechanism involved in cellular communication between female reproductive system cells and oocyte mediated by extracellular vesicles and their impacts on oocyte maturation, fertilization and bovine embryo cleavage
Grantee:Ana Clara Faquineli Cavalcante Mendes de Ávila
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 14/22887-0 - Cell-secreted vesicles containing miRNAs modulate epigenetic changes during in vitro culture of bovine gametes and embryos
Grantee:Juliano Coelho da Silveira
Support Opportunities: Research Grants - Young Investigators Grants