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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New cathepsin V inhibitor from stems of Bowdichia virgilioides

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Author(s):
Silva, Taynara L. [1] ; Fernandes, Joao B. [1] ; Silva, M. Fatima das G. F. [1] ; Consolaro, Helder N. [2] ; de Sousa, Lorena R. F. [1, 2] ; Vieira, Paulo C. [3, 1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP - Brazil
[2] Univ Fed Goias Reg Catalano, Unidade Acad Especial Quim, Catalano, Go - Brazil
[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 29, n. 4, p. 491-494, JUL-AUG 2019.
Web of Science Citations: 0
Abstract

Bioassay-guided fractionation of Bowdichia virgilioides Kunth, Fabaceae, extracts has led to the isolation of cathepsin V inhibitors. The investigation of the hexane and ethyl acetate extracts allowed the characterization of eleven compounds: lupeol, lupenone, beta-sitosterol and stigmasterol in mixture, trans p-coumaric acid ester derivative, syringaresinol, bowdenol, 8-methoxycoumestrol, 3,4-hydroxy-7-methoxyisoflavone, 7,3'-dihydroxy-4'-methoxyisoflavone, and 5,4'-dihydroxy-7'-methoxyisoflavone. Structures of compounds were stablished by 1D and 2D NMR, and MS experiments. Among the isolated compounds, trans p-coumaric acid ester derivative and 8-methoxycoumestrol showed significant inhibition on cathepsin V, which is up to now unexplored. (C) 2019 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. (AU)

FAPESP's process: 12/11819-8 - Chemical study of Bowdichia virgilioides (Fabaceae) ón searching for selective inhibitors of cysteine peptidases
Grantee:Taynara Lopes Silva
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/25299-6 - Integrated studies for leaf cutting control
Grantee:João Batista Fernandes
Support type: Research Projects - Thematic Grants