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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Experimental Measurements of the [CO2 (1) + Acetone (2) + Ivermectin (3)] System at High Pressure

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Author(s):
Valarini Junior, Osvaldo [1, 2] ; Ferreira-Pinto, Leandro [3] ; Cabral, Vladimir Ferreira [1] ; Giufrida, Willyan Machado [1, 2] ; Cardozo-Filho, Lucio [1, 4]
Total Authors: 5
Affiliation:
[1] Univ Estadual Maringa, Dept Chem Engn, BR-87020900 Maringa, PR - Brazil
[2] Fac Engn & Arquitetura FEITEP, BR-87070130 Maringa, PR - Brazil
[3] Sao Paulo State Univ UNESP, Dept Energy Engn, BR-01049010 Rosana, SP - Brazil
[4] Ctr Univ Fundacao Ensino Octavio Bastos UNIFEOB, Res Ctr, BR-13874149 Sao Joao Da Boa Vista, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF CHEMICAL AND ENGINEERING DATA; v. 64, n. 9, p. 3786-3792, SEP 2019.
Web of Science Citations: 0
Abstract

For potential application to the controlled release of ivermectin from nanoparticle preparations, this study discloses experimental data on the phase transitions in the CO2, acetone, and ivermectin system subjected to high pressures. The data were acquired via the static synthetic method with a variable-volume view cell in the temperature range of 303.15-333.15 K at pressures up to 10 MPa using three concentrations of ivermectin Bla in acetone (0.029, 0.043, and 0.058 mol.kg(-1)) and CO2 molar fractions of 0.3-0.9. Vapor-liquid-type phase transitions were observed, characterized as bubbles in the presence or absence of a solid phase. A solid phase was formed for all ivermectin Bla concentrations evaluated in this study. Determination of the region of precipitation of ivermectin is important for identifying the concentration of the acetone/ivermectin mixture where CO2 will act strongly as an antisolvent. Thermodynamic modeling was performed by considering the system as pseudo-ternary based on the low concentration of ivermectin Bla in the system. Thermodynamics modeling using the Peng(-) Robinson cubic state equation with the van der Waals mixing rule (PR-vdW2) adequately described the experimentally observed trends. (AU)

FAPESP's process: 18/23063-1 - Phase and kinetic equilibrium study using Supercritical CO2 from the extraction of essential oils from plant matrices with anxiolytic potentials from the Paranapanema region
Grantee:Leandro Ferreira Pinto
Support type: Regular Research Grants