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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bioactive Aliphatic Sulfates from Marine Invertebrates

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Kellner Filho, Luis C. [1] ; Picao, Bruno W. [1] ; Silva, Marcio L. A. [1] ; Cunha, Wilson R. [1] ; Pauletti, Patricia M. [1] ; Dias, Gustavo M. [2] ; Copp, Brent R. [3] ; Bertanha, Camila S. [1] ; Januario, Ana H. [1]
Total Authors: 9
[1] Univ Franca, Ctr Res Exact & Technol Sci, BR-14404600 Franca, SP - Brazil
[2] Fed Univ ABC, Ctr Nat & Human Sci, BR-09606070 Sao Bernardo Do Campo, SP - Brazil
[3] Univ Auckland, Sch Chem Sci, Auckland 1142 - New Zealand
Total Affiliations: 3
Document type: Review article
Source: MARINE DRUGS; v. 17, n. 9 SEP 2019.
Web of Science Citations: 0

The occurrence of sulfated steroids and phenolics in marine organisms is quite widespread, being typically reported from Echinoderms. In contrast, alkane and alkene aliphatic sulfates are considerably rarer with examples being reported from a diverse array of organisms including echinoderms, sponges and ascidians. While no ecological roles for these metabolites have been proposed, they do exhibit a diverse array of biological activities including thrombin inhibition; the ability to induce metamorphosis in larvae; antiproliferative, antibacterial and antifungal properties; and metalloproteinase inhibition. Of particular interest and an avenue for future development is the finding of antifouling properties with low or nontoxic effects to the environment. This review focuses on alkyl sulfates and related sulfamates, their structures and biological activities. Spectroscopic and spectrometric techniques that can be used to recognize the presence of sulfate groups are also discussed, data for which will enhance the ability of researchers to recognize this class of chemically- and biologically-interesting marine natural products. (AU)

FAPESP's process: 17/14261-1 - Investigation of the schistosomicidal, leishmanicidal and cytototoxic potential of fungal lineages associated with marine invertebrates belonging to Ascidiacea
Grantee:Ana Helena Januário
Support type: Regular Research Grants
FAPESP's process: 14/19184-7 - Schistosomicidal potential investigation of marine invertebrates belonging to the Ascidiacea family
Grantee:Ana Helena Januário
Support type: Regular Research Grants