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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Estrogen Receptor, Progesterone Receptor, and HER-2 Expression in Recurrent Pleomorphic Adenoma

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Author(s):
de Souza, Ana Amelia [1] ; Altemani, Albina [2] ; de Araujo, Ney Soares [1] ; Texeirai, Lucas Novaes [1] ; de Araujo, Vera Cavalcanti [1] ; Soares, Andresa Borges [1]
Total Authors: 6
Affiliation:
[1] Sao Leopoldo Mand Inst & Res Ctr, Dept Oral Pathol, Dr Jose Rocha Junquelra St, 13 Pte, BR-13045755 Campinas, SP - Brazil
[2] State Univ Campinas UNICAMP, Sch Med, Dept Pathol, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CLINICAL PATHOLOGY; v. 12, SEP 2019.
Web of Science Citations: 0
Abstract

Pleomorphic adenoma (PA) is the most common salivary gland neoplasm and, although mostly benign, recurrences, being called recurrent pleomorphic adenoma (RPA) and malignant transformation to carcinoma ex pleomorphic adenoma (CXPA), do occur. Recently, attention has been focused on molecular targeted cancer therapy in various tumors, including salivary gland tumors. The aim of this study was to investigate the role of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) in PA, RPA, and CXPA. In total, 20 cases of PA, 18 of RPA, and 7 cases of CXPA were immunohistochemically studied for ER, PR, and HER-2. For evaluation of ER and PR, only nuclear expression and greater than 10% positive cells were regarded as cutoff criteria. HER-2 was evaluated semiquantitatively and graded from 0 to 3+. HER-2 amplification was assessed by chromogenic in situ hybridization (CISH). Tumors were negative for ER, PR, and HER-2 in all cases of PA and RPA. A case of CXPA showed moderate and complete membranous staining, and 6 cases were negative. HER-2 amplification was not observed in any case. In conclusion, the lack of ER, PR, and HER-2 expression in PA, RPA, and CXPA suggests that these proteins are not involved in progression, recurrence, or malignant transformation of PA. (AU)

FAPESP's process: 14/25173-8 - Expression of hormonal factors and extracellular matrix proteins in recurrent pleomorphic adenoma
Grantee:Andresa Borges Soares
Support Opportunities: Regular Research Grants