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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease

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Mori, Marcelo A. [1] ; Ludwig, Raissa G. [1] ; Garcia-Martin, Ruben [2] ; Brandao, Bruna B. [2] ; Kahn, C. Ronald [2]
Total Authors: 5
[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil
[2] Harvard Med Sch, Sect Integrat Physiol & Metab, Joslin Diabet Ctr, Boston, MA 02115 - USA
Total Affiliations: 2
Document type: Review article
Source: Cell Metabolism; v. 30, n. 4, p. 656-673, OCT 1 2019.
Web of Science Citations: 3

miRNAs can be found in serum and other body fluids and serve as biomarkers for disease. More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as exosomes, may mediate paracrine and endocrine communication between different tissues and thus modulate gene expression and the function of distal cells. When impaired, these processes can lead to tissue dysfunction, aging, and disease. Adipose tissue is an especially important contributor to the pool of circulating exosomal miRNAs. As a result, alterations in adipose tissue mass or function, which occur in many metabolic conditions, can lead to changes in circulating miRNAs, which then function systemically. Here we review the findings that led to these conclusions and discuss how this sets the stage for new lines of investigation in which extracellular miRNAs are recognized as important mediators of intercellular communication and potential candidates for therapy of disease. (AU)

FAPESP's process: 17/23920-9 - Varredura e caracterização de moléculas circulantes que afetam o gasto energético
Grantee:Raissa Guimarães Ludwig
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/07975-8 - Exploring the role of adipose tissue-derived circulating miRNAs in the beneficial effects of exercise training
Grantee:Marcelo Alves da Silva Mori
Support Opportunities: Regular Research Grants
FAPESP's process: 17/01184-9 - CAMeLEOm: cross-species analysis of metabolic, lifespan effects and omics of dietary restriction mimetics
Grantee:Marcelo Alves da Silva Mori
Support Opportunities: Research Projects - Thematic Grants