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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Short-term cryotherapy did not substantially reduce pain and had unclear effects on physical function and quality of life in people with knee osteoarthritis: a randomised trial

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Dantas, Lucas Ogura [1] ; Breda, Carolina Carreira [1] ; Mendes da Silva Serrao, Paula Regina [1] ; Aburquerque-Sendin, Francisco [2, 3] ; Serafim Jorge, Ana Elisa [1] ; Cunha, Jonathan Emanuel [1] ; Barbosa, Germanna Medeiros [1] ; Quagliotti Durigan, Joao Luiz [4] ; Salvini, Tania de Fatima [1]
Total Authors: 9
[1] Univ Fed Sao Carlos, Phys Therapy Dept, Sao Carlos, SP - Brazil
[2] Inst Maimonides Invest Biomed Cordoba, Cordoba - Spain
[3] Univ Cordoba, Dept Ciencias Sociosanit Radiol & Med Fis, Cordoba - Spain
[4] Univ Brasilia, Phys Therapy Div, Dist Fed - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF PHYSIOTHERAPY; v. 65, n. 4, p. 215-221, OCT 2019.
Web of Science Citations: 0

Objective: Does short-term cryotherapy improve pain, function and quality of life in people with knee osteoarthritis (OA)? Design: Randomised controlled trial with concealed allocation, blinded assessment of some outcomes, and intention-to-treat analysis. Participants: People living in the community with knee OA. Interventions: The experimental group received cryotherapy, delivered as packs of crushed ice applied to the knee with mild compression. The control group received the same regimen but with sham packs filled with sand. The interventions were applied once a day for 4 consecutive days. Outcome measures: Participants were assessed at baseline and on the day after the 4-day intervention period. The primary outcome was pain intensity according to a visual analogue scale. Secondary outcomes were baseline to post-intervention changes according to the Western Ontario and McMaster Universities Osteoarthritis, Knee injury and Osteoarthritis Outcome; Timed Up and Go test; and 30-Second Chair to Stand test. Results: Sixty participants were randomised into the experimental group (n = 30) or the control group (n = 30). Twenty-nine participants from each group completed the trial. The mean between-group difference in change in pain severity was -0.8 cm (95% CI -1.6 to 0.1), where negative values favour the experimental group. This result did not reach the nominated smallest worthwhile effect of 1.75 cm. The secondary outcomes had less-precise estimates, with confidence intervals that spanned worthwhile, trivial and mildly harmful effects. Conclusion: Short-term cryotherapy was not superior to a sham intervention in terms of relieving pain or improving function and quality of life in people with knee OA. Although cryotherapy is considered to be a widely used resource in clinical practice, this study does not suggest that it has an important short-term effect, when compared with a sham control, as a non-pharmacological treatment for people with knee osteoarthritis. (C) 2019 Australian Physiotherapy Association. Published by Elsevier B.V. (AU)

FAPESP's process: 11/22122-5 - Study of the biomechanical, sensorial, cardiorespiratory and quality of life adaptations associated to physical therapy intervention in the fibromyalgic syndrome
Grantee:Tania de Fatima Salvini
Support type: Research Projects - Thematic Grants
FAPESP's process: 15/21422-6 - The effect of cryotherapy in pain control, function and quality of life in individuals with knew osteoarthritis: randomized clinical trial
Grantee:Lucas Ogura Dantas
Support type: Scholarships in Brazil - Doctorate (Direct)