| Full text | |
| Author(s): |
Ana Paula Carvalho Reis
;
Franciele Fernandes Correia
;
Thais Martins Jesus
;
Carla Pagliari
[4]
;
Neusa Y Sakai-Valente
[5]
;
Walter Belda Júnior
[6]
;
Paulo Ricardo Criado
[7]
;
Gil Benard
;
Maria Gloria Teixeira Sousa
Total Authors: 9
|
| Document type: | Journal article |
| Source: | Revista do Instituto de Medicina Tropical de São Paulo; v. 61, 2019-10-10. |
| Abstract | |
ABSTRACT Dermatophytosis is a cutaneous mycosis caused by a plethora of keratinophilic fungi, but Trichophyton rubrum is the most common etiological agent. Despite its high prevalence worldwide, little is known about the host defense mechanisms in this infection, particularly the in situ immune response. Using an immunohistochemistry approach, we investigated the density of CD1a+, factor XIIIa+ and CD68+ cells in the skin of dermatophytosis patients. Langerhans cells (CD1a+ cells) were significantly decreased in the epidermis of patients, both in affected and unaffected areas. In the dermis, however, no differences in the density of macrophages (CD68+ cells) and dermal dendrocytes (factor XIIIa+ cells) were observed. These results suggest that the decreased number of Langerhans cells may be a risk factor for development of dermatophytosis. (AU) | |
| FAPESP's process: | 17/26208-8 - Chronic disseminated dermatophytosis due to Trichophyton rubrum: role of neutrophils in the effector mechanisms and in the modulation of the adaptive response of the human infection |
| Grantee: | Maria da Gloria Sousa Stafocker |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 16/16369-1 - Chronic disseminated dermatophytosis due to Trichophyton rubrum: role of neutrophils in the effector mechanisms and in the modulation of the adaptive response of the human infection |
| Grantee: | Maria da Gloria Sousa Stafocker |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 18/24175-8 - In situ immune response in human disseminated chronic dermatophytosis: participation of C type Lectin receptors. |
| Grantee: | Ana Paula Carvalho dos Reis |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |