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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy

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Author(s):
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Ishibazawa, Akihiro [1, 2] ; De Pretto, Lucas R. [3, 4, 5] ; Alibhai, A. Yasin [1] ; Moult, Eric M. [3, 4] ; Arya, Malvika [1] ; Sorour, Osama [1] ; Mehta, Nihaal [1] ; Baumal, Caroline R. [1] ; Witkin, Andre J. [1] ; Yoshida, Akitoshi [2] ; Duker, Jay S. [1] ; Fujimoto, James G. [3, 4] ; Waheed, Nadia K. [1]
Total Authors: 13
Affiliation:
[1] Tufts Med Ctr, New England Eye Ctr, 800 Washington St, Box 450, Boston, MA 02111 - USA
[2] Asahikawa Med Univ, Dept Ophthalmol, Asahikawa, Hokkaido - Japan
[3] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 - USA
[4] MIT, Res Lab Elect, 77 Massachusetts Ave, Cambridge, MA 02139 - USA
[5] Nucl & Energy Res Inst, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE; v. 60, n. 13, p. 4310-4318, OCT 2019.
Web of Science Citations: 0
Abstract

PURPOSE. To evaluate whether retinal capillary nonperfusion is found predominantly adjacent to arteries or veins in eyes with diabetic retinopathy (DR). METHODS. Sixty-three eyes from 44 patients with proliferative DR (PDR) or non-PDR (NPDR) were included. Images (12 x 12-mm) foveal-centered optical coherence tomography (OCT) angiography (OCTA) images were taken using the Zeiss Plex Elite 9000. In 37 eyes, widefield montages with five fixation points were also obtained. A semiautomatic algorithm that detects nonperfusion in full-retina OCT slabs was developed, and the percentages of capillary nonperfusion within the total image area were calculated. Retinal arteries and veins were manually traced. Based on the shortest distance, nonperfusion pixels were labeled as either arterial-side or venous-side. Arterial-adjacent and venous-adjacent nonperfusion and the A/V ratio (arterial-adjacent nonperfusion divided by venous-adjacent nonperfusion) were quantified. RESULTS. Twenty-two eyes with moderate NPDR, 16 eyes with severe NPDR, and 25 eyes with PDR were scanned. Total nonperfusion area in PDR (median: 8.93%) was greater than in moderate NPDR (3.49%, P < 0.01). Arterial-adjacent nonperfusion was greater than venous-adjacent nonperfusion for all stages of DR (P < 0.001). The median A/V ratios were 1.93 in moderate NPDR, 1.84 in severe NPDR, and 1.78 in PDR. The A/V ratio was negatively correlated with the total nonperfusion area (r = -0.600, P < 0.0001). The results from the widefield montages showed similar patterns. CONCLUSIONS. OCTA images with arteries and veins traced allowed us to estimate the nonperfusion distribution. In DR, smaller nonperfusion tends to be arterial-adjacent, while larger nonperfusion tends toward veins. (AU)

FAPESP's process: 16/17342-0 - Application of speckle analysis techniques in OCT for optical diagnosis in vivo
Grantee:Lucas Ramos de Pretto
Support Opportunities: Scholarships abroad - Research Internship - Doctorate