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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Non-enzymatic electrochemical determination of creatinine using a novel screen-printed microcell

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Fava, Elson Luiz [1] ; do Prado, Thiago Martimiano [1] ; Garcia-Filho, Amauri [1] ; Silva, Tiago Almeida [1, 2] ; Cincotto, Fernando Henrique [3, 1] ; de Moraes, Fernando Cruz [1] ; Faria, Ronaldo Censi [1] ; Fatibello-Filho, Orlando [1]
Total Authors: 8
[1] Univ Fed Sao Carlos, Dept Chem, POB 676, BR-13560970 Sao Carlos, SP - Brazil
[2] Fed Ctr Technol Educ Minas Gerais, Dept Met & Chem, BR-35180008 Timoteo, MG - Brazil
[3] Univ Fed Rio de Janeiro, Inst Chem, Rio De Janeiro, RJ - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Talanta; v. 207, JAN 15 2020.
Web of Science Citations: 0

A low-cost and disposable microcell was constructed with a screen-printed electrode for the non-enzymatic electrochemical determination of creatinine. The working electrode was modified with carbon black and maintained in contact with paper-adsorbed iron (III) ions. A small sample volume of 3 mu L was required for the device operation. Then, iron (III) ions were complexed in the presence of creatinine in a chemical step, followed by an electrochemical reduction of non-complexed metallic ions in excess. Cyclic voltammetry and differential-pulse voltammetry experiments were employed for the electrochemical characterizations and analytical performance evaluation of the microcell. The working electrode modification with carbon black provided a significant increase of analytical signal. The sensor presented a linear response for creatinine concentrations ranging from 0.10 to 6.5 mmol L-1, with a limit of detection of 0.043 mmol L-1. Experiments for creatinine determination in real samples were successful performed through of standard recovery in urine. (AU)

FAPESP's process: 17/24053-7 - Development of simple electrochemical methods for the detection of biomarkers for the diagnosis of diseases
Grantee:Ronaldo Censi Faria
Support type: Regular Research Grants
FAPESP's process: 16/10012-4 - Development of a disposable biosensors array with a microfluidic device for multiplex determination of species of biological interest in different matrices
Grantee:Elson Luiz Fava
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/10118-0 - Study and application of electrochemical technology for the analysis and degradation of endocrine interferents: materials, sensors, processes and scientific dissemination
Grantee:Marcos Roberto de Vasconcelos Lanza
Support type: Research Projects - Thematic Grants