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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Preparation and properties of α-tricalcium phosphate microspheres by spray drying

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C. O. Renó ; R. G. Carrodeguas ; M. Motisuke ; M. A. Rodríguez
Total Authors: 4
Document type: Journal article
Source: Cerâmica; v. 65, n. 376, p. 599-604, Dez. 2019.

Abstract a-TCP microspheres were obtained by atomizing aqueous slurries containing 50 wt% of low crystallinity α-TCP and 1 wt% of citric acid. Poly(ethylene glycol) and poly(vinyl alcohol) were tested as a binder. The spray drying process yielded to microspheres with mean diameter around 20 μm and sphericity (horizontal and vertical length ratio) closest to one, which is essential to many applications, such as drug delivery and injectability of cements. The addition of binders was necessary to decrease the amount of loose particles and to improve powder flowability but it also caused a reduction in wettability and surface area. Best results were achieved with 3 wt% of PVA, as the microspheres presented the highest specific surface area, wettability, and sphericity. The microspheres prepared in this study may be used as injectable bone cements precursor since their geometry and flowability would favor paste homogeneity and injectability overcoming many drawbacks of today’s injectable bone cements. (AU)

FAPESP's process: 13/19642-2 - Injectable bone cements: optimizing and controlling mechanical resistance, porosity and degradation rate
Grantee:Mariana Motisuke
Support type: Regular Research Grants
FAPESP's process: 13/03208-1 - Microspheres of calcium phosphate obtained by spray drying
Grantee:Caroline de Oliveira Renó
Support type: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 13/26248-9 - Strotium and silicon co-doped calcium phosphate cement: injectability evaluation and mechanical properties optimization
Grantee:Caroline de Oliveira Renó
Support type: Scholarships in Brazil - Doctorate (Direct)