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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Unraveling genomic associations with feed efficiency and body weight traits in chickens through an integrative approach

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Author(s):
Monteiro Moreira, Gabriel Costa [1] ; Poleti, Mirele Daiana [2] ; Pertille, Fabio [1] ; Boschiero, Clarissa [1] ; Mello Cesar, Aline Silva [1] ; Godoy, Thais Fernanda [1] ; Ledur, Monica Correa [3] ; Reecy, James M. [4] ; Garrick, Dorian J. [5] ; Coutinho, Luiz Lehmann [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Dept Anim Sci, BR-13418900 Piracicaba, SP - Brazil
[2] Univ Sao Paulo, Coll Anim Sci & Food Engn FZEA, Pirassununga, SP - Brazil
[3] Embrapa Suinos & Aves, Concordia, SC - Brazil
[4] ISU, Dept Anim Sci, Ames, IA - USA
[5] Massey Univ, Sch Agr, Hamilton - New Zealand
Total Affiliations: 5
Document type: Journal article
Source: BMC GENETICS; v. 20, n. 1 NOV 6 2019.
Web of Science Citations: 0
Abstract

Background Feed efficiency and growth rate have been targets for selection to improve chicken production. The incorporation of genomic tools may help to accelerate selection. We genotyped 529 individuals using a high-density SNP chip (600 K, Affymetrix (R)) to estimate genomic heritability of performance traits and to identify genomic regions and their positional candidate genes associated with performance traits in a Brazilian F-2 Chicken Resource population. Regions exhibiting selection signatures and a SNP dataset from resequencing were integrated with the genomic regions identified using the chip to refine the list of positional candidate genes and identify potential causative mutations. Results Feed intake (FI), feed conversion ratio (FC), feed efficiency (FE) and weight gain (WG) exhibited low genomic heritability values (i.e. from 0.0002 to 0.13), while body weight at hatch (BW1), 35 days-of-age (BW35), and 41 days-of-age (BW41) exhibited high genomic heritability values (i.e. from 0.60 to 0.73) in this F-2 population. Twenty unique 1-Mb genomic windows were associated with BW1, BW35 or BW41, located on GGA1-4, 6-7, 10, 14, 24, 27 and 28. Thirty-eight positional candidate genes were identified within these windows, and three of them overlapped with selection signature regions. Thirteen predicted deleterious and three high impact sequence SNPs in these QTL regions were annotated in 11 positional candidate genes related to osteogenesis, skeletal muscle development, growth, energy metabolism and lipid metabolism, which may be associated with body weight in chickens. Conclusions The use of a high-density SNP array to identify QTL which were integrated with whole genome sequence signatures of selection allowed the identification of candidate genes and candidate causal variants. One novel QTL was detected providing additional information to understand the genetic architecture of body weight traits. We identified QTL for body weight traits, which were also associated with fatness in the same population. Our findings form a basis for further functional studies to elucidate the role of specific genes in regulating body weight and fat deposition in chickens, generating useful information for poultry breeding programs. (AU)

FAPESP's process: 14/21380-9 - Genome wide association studies for fat deposition and carcass yield in chickens
Grantee:Gabriel Costa Monteiro Moreira
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/20440-3 - Epigenetic analysis of methylation profile of chickens submitted to different stress conditions in the livestock production environment
Grantee:Fábio Pértille
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/00569-1 - IMPUTATION AND GENOME-WIDE ASSOCIATION ANALYSIS USING HAPLOTYPES FOR ABDOMINAL FAT IN CHICKENS.
Grantee:Gabriel Costa Monteiro Moreira
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/08704-0 - Identification of loci of interest for poultry production
Grantee:Luiz Lehmann Coutinho
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/00616-7 - Identification and characterization of CNVs in chicken genome and association with development of breast muscle
Grantee:Thaís Fernanda Godoy
Support Opportunities: Scholarships in Brazil - Doctorate