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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

S-nitrosothiols and H2S donors: Potential chemo-therapeutic agents in cancer

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Cardoso Amorim Reis, Adriana Karla [1] ; Stern, Arnold [2] ; Monteiro, Hugo Pequeno [3]
Total Authors: 3
[1] Univ Fed Sao Paulo, Dept Chem, Inst Environm Chem & Pharmaceut Sci, Campus Diadema, Sao Paulo, SP - Brazil
[2] NYU, Sch Med, New York, NY 10003 - USA
[3] Univ Fed Sao Paulo, Dept Biochem, Ctr Cellular & Mol Therapy, Campus Sao Paulo, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: REDOX BIOLOGY; v. 27, n. SI OCT 2019.
Web of Science Citations: 2

Nitric Oxide (NO) and Hydrogen Sulfide (H2S) are components of an ``interactome{''}, which is defined as a redox system involving the interactions of RSS, RNS and ROS. Chemical interaction by these species is common and is characterized by one and two electron oxidation, nitrosylation, nitration and sulfuration/polysulfidation reactions. NO and H2S are gases that penetrate cell membranes, are synthesized by specific enzymes, are ubiquitous, regulate protein activities through post-translational modifications and participate in cell signaling. The two molecules at high concentrations compared to physiological concentrations may result in cellular damage particularly through their interaction with other reactive species. NO and H2S can interact with each other and form a variety of molecular species which may have constructive or destructive behavior depending on the cell type, the cellular environment (ex. oxygen tension, pH, redox state), where the products are produced and in what concentrations. Cross talk exists between NO and H2S, whereby they can influence the generation and signaling behavior of each other. Given the above mentioned properties of NO and H2S and studies in cancer cells and animal models employing NO and H2S donors that generate higher than physiological concentrations of NO and H2S and are effective in killing cancer cells but not normal cells, lend credence to the possibility of the utility of these donors in an approach to the treatment of cancer. (AU)

FAPESP's process: 12/10470-1 - A role for nitric oxide and for the inducible isoform of nitric oxide synthase in human colon cancer progression
Grantee:Hugo Pequeno Monteiro
Support type: Regular Research Grants
Grantee:Elaine Guadelupe Rodrigues
Support type: Regular Research Grants