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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aerobic Exercise Training and Nontraditional Cardiovascular Risk Factors in Hemodialysis Patients: Results from a Prospective Randomized Trial

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Oliveira e Silva, Viviana Rugolo [1] ; Belik, Fernanda Stringuetta [1] ; Hueb, Joao Carlos [2] ; Goncalves, Renato de Souza [2] ; Teixeira Caramori, Jacqueline Costa [1] ; Vogt, Barbara Perez [1] ; Barretti, Pasqual [1] ; Zanati Bazan, Silmeia Garcia [2] ; Mengue Feniman De Stefano, Greicy Mara [1] ; Martin, Luis Cuadrado [1] ; da Silva Franco, Roberto Jorge [1]
Total Authors: 11
Affiliation:
[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Nephrol, BR-18618687 Botucatu, SP - Brazil
[2] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Cardiol, Botucatu, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CARDIORENAL MEDICINE; v. 9, n. 6, p. 391-399, NOV 2019.
Web of Science Citations: 0
Abstract

Introduction: Chronic kidney disease (CKD) patients have a high incidence of cardiovascular diseases (CVD) which increases their morbidity and mortality. A sedentary lifestyle in CKD is directly linked to the onset of CVD. Physical activity can bring beneficial effects to CKD patients. Aims: The aim of this study was assess the impact of aerobic training on nontraditional cardiovascular risk factors in CKD patients on hemodialysis. Materials and Methods: This is a prospective, controlled, and randomized clinical trial with analysis of intention to treat. Thirty patients underwent an exercise treadmill test, an arterial stiffness evaluation, echocardiography and analysis of endothelial reactivity, and carotid ultrasound and laboratorial tests, including analysis of serum aldosterone. The intervention group (IG) (n =15) underwent aerobic exercise during hemodialysis 3 times a week for 4 months. The control group (CG) (n =15) had no intervention. All of the patients were reassessed after 4 months. Results: In the IG, there was a statistically significant improvement in flow-mediated vasodilation (FMV; p = 0.002) and a reduction in left ventricular hypertrophy (p = 0.006) and serum aldosterone (p = 0.016). There was an increase in C-reactive protein in the CG (p = 0.002). Conclusion: This aerobic training protocol was able to improve endothelial function with enhanced FMV and reduce left ventricular hypertrophy and serum aldosterone, which could have a positive impact on the reduction of nontraditional cardiovascular risk factors in CKD patients on hemodialysis. (AU)

FAPESP's process: 09/02060-5 - PHYSICAL ACTIVITY EFFECT ON HOME BLOOD PRESSURE, CENTRAL BLOOD PRESSURE AND PULSE WAVE VELOCITY IN HEMODIALYSIS PATIENTS
Grantee:Roberto Jorge da Silva Franco
Support type: Regular Research Grants