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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior

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Author(s):
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de Jesus Paniza, Ana Carolina [1] ; Mendes, Thais Biude [1] ; Borges Vianna, Matheus Duarte [1] ; Dias Thomaz, Debora Mota [1] ; Chiappini, Paula B. O. [2] ; Colazza-Gama, Gabriel A. [1] ; Lindsey, Susan Chow [3] ; de Carvalho, Marcos Brasilino [4] ; Ferreira Alves, Venancio Avancini [5] ; Curioni, Otavio [4] ; Bastos, Andre Uchimura [6, 1] ; Cerutti, Janete Maria [1]
Total Authors: 12
Affiliation:
[1] Univ Fed Sao Paulo, Genet Bases Thyroid Tumors Lab, Dept Morphol & Genet, Div Genet, Sao Paulo, SP - Brazil
[2] Hosp Heliopolis, Dept Pathol, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Lab Mol & Translat Endocrinol, Dept Med, Div Endocrinol, Sao Paulo, SP - Brazil
[4] Hosp Heliopolis, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Fac Med, Dept Pathol, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, Sao Paulo, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: ENDOCRINE CONNECTIONS; v. 8, n. 11, p. 1529-1538, NOV 2019.
Web of Science Citations: 0
Abstract

The recent reclassification of a follicular variant of papillary thyroid carcinoma (FVPTC), subset as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), aims to avoid overtreatment of patients with an indolent lesion. The diagnosis of NIFTP has recently been revisited using more rigid criteria. This study presents histological and molecular findings and a long clinical follow-up of 94 FVPTC, 40 cases of follicular adenoma (FTA) and 22 cases of follicular carcinoma (FTC) that were classified before the advent of the NIFTP reclassification. All slides were reviewed using these rigid criteria and analysis of numerous sections of paraffin blocks and reclassified as 7 NIFTPs, 2 EFVPTCs, 29 infiltrative FVPTC (IFVPTCs), 57 invasive EFVPTC (I-EFVPTCs), 39 FTAs and 22 FTCs. Remarkably, EFVPTC and NIFTP patients were all free of disease at the end of follow-up and showed no BRAF mutation. Only one NIFTP sample harbored mutations, an NRAS Q61R. PAX8/PPARG fusion was found in I-EFVPTCs and FTC. Although additional studies are needed to identify a specific molecular profile to aid in the diagnosis of lesions with borderline morphological characteristics, we confirmed that the BRAFV600E mutation is an important tool to exclude the diagnosis of NIFTP. We also show that rigorous histopathological criteria should be strongly followed to avoid missing lesions in which more aggressive behavior is present, mainly via the analysis of capsule or vascular invasion and the presence of papillary structures. (AU)

FAPESP's process: 17/06487-0 - Identification of the metabolic profile of cells with ectopic expression of PVALB and investigation of the molecular mechanism associated with its expression in Hürthle cell adenomas
Grantee:Thais Biude Mendes
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/06570-6 - Comprehensive whole exome, paired-end RNA and genome sequencing: new insights into genetic bases of thyroid carcinoma in pediatric and adult ages and applications in clinical practice
Grantee:Janete Maria Cerutti
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/25784-2 - Resistance mechanisms to treatment with temozolomide in glioma cells
Grantee:André Uchimura Bastos
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/16315-1 - Analysis of the prevalence of STRN-ALK rearrangement in Hürthle cell tumors
Grantee:Débora Mota Dias Thomaz
Support type: Scholarships in Brazil - Scientific Initiation