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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enhanced water uptake of PHBV scaffolds with functionalized cellulose nanocrystals

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do Amaral Montanheiro, Thais Larissa [1, 2] ; Montagna, Larissa Stieven [2] ; Patrulea, Viorica [3] ; Jordan, Olivier [3] ; Borchard, Gerrit [3] ; Ribas, Renata Guimaraes [1] ; Bastos Campos, Tiago Moreira [1] ; Thim, Gilmar Patrocinio [1] ; Lemes, Ana Paula [2]
Total Authors: 9
[1] Technol Inst Aeronaut ITA, LPP, Praca Marechal Eduardo Gomes, 50 Vila Acacias, BR-12228900 Sao Jose Dos Campos, SP - Brazil
[2] Fed Univ Sao Paulo Unifesp, Technol Lab Polymers & Biopolymers TecPBio, Talim, 330 Vila Nair, BR-12231280 Sao Jose Dos Campos, SP - Brazil
[3] Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci, 1 Rue Michel Servet, CH-1205 Geneva - Switzerland
Total Affiliations: 3
Document type: Journal article
Source: Polymer Testing; v. 79, OCT 2019.
Web of Science Citations: 0

Super hydrophilic scaffolds of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) with 3 wt % of acetylated (CNC-Ac) and PEGylated (CNC-PEG) cellulose nanocrystals (CNC) were prepared. PHBV, PHBV/CNC-Ac, and PHBV/CNC-PEG scaffolds were characterized with respect to their morphology by scanning electron microscopy (SEM) and X-ray microtomography. The crystallinity was evaluated by differential scanning calorimetry (DSC) and the mechanical properties by uniaxial compression tests. The presence of residual solvent was identified by gas chromatography (GC), wettability measured by static contact angle and aqueous adsorption by gravimetry. All the scaffolds showed porous morphology, being that, for neat PHBV the morphology was more regular with oriented pores. The porosity was reduced by 26% with the introduction of CNC-Ac and CNC-PEG, and the compression modulus increased by 25% and 72% for PHBV/CNC-Ac and PHBV/CNC-PEG scaffolds, respectively, compared to neat PHBV. Even with lower porosities, PHBV/CNC-Ac and PHBV/CNC-PEG adsorbed 16% and 67% more water than PHBV scaffold, following the intraparticle diffusion model for all the samples. No residual solvents were found and the crystallinity was slightly increased upon addition of CNC-Ac and CNC-PEG. Therefore, the addition of CNC-Ac and CNC-PEG can improve both compressive modulus and water uptake, turning PHBV nanocomposite scaffolds suitable for tissue engineering applications. (AU)

FAPESP's process: 17/24873-4 - PHBV and hydroxybutyrate functionalized CNT nanocomposite: kinetic study of crystallization and correlation with mechanical properties
Grantee:Thaís Larissa do Amaral Montanheiro
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/27064-9 - Utilization of cellulose nanocrystals in the production of polymer nanocomposites for applications in the medical area
Grantee:Ana Paula Lemes
Support type: Regular Research Grants