| Full text | |
| Author(s): |
Calvo, Fabricio
[1, 2, 3]
;
Almada, Rafael Carvalho
[4, 1]
;
da Silva, Juliana Almeida
[4, 1]
;
Medeiros, Priscila
[1]
;
Soares, Jr., Raimundo da Silva
[1]
;
de Paiva, Yara Bezerra
[1]
;
Roncon, Camila Marroni
[1, 5]
;
Coimbra, Norberto Cysne
[4, 1, 6]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo FMRP USP, Lab Neuroanat & Neuropsychobiol, Dept Pharmacol, Sch Med Ribeirao Preto, Ribeirao Preto - Brazil
[2] Sao Lucas Coll, Dept Pharmacol, Porto Velho - Brazil
[3] Aparicio Carvalho Integrat Coll FIMCA, Porto Velho - Brazil
[4] Inst Neurosci & Behav INeC, Ribeirao Preto - Brazil
[5] Assis Cty Educ Fdn FEMA, Assis - Brazil
[6] Univ Sao Paulo FMRP USP, NAP USP Neurobiol Emot Res Ctr NuPNE, Sch Med Ribeirao Preto, Ribeirao Preto - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | NEUROPSYCHOBIOLOGY; v. 78, n. 4, p. 218-228, NOV 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: Gamma-aminobutyric acid (GABA)ergic and opioid systems play a crucial role in the neural modulation of innate fear organised by the inferior colliculus (IC). In addition, the IC is rich in GABAergic fibres and opioid neurons, which are also connected to other mesencephalic structures, such as the superior colliculus and the substantia nigra. However, the contribution of distinct opioid receptors (ORs) in the IC during the elaboration and expression of innate fear and panic-like responses is unclear. The purpose of the present work was to investigate a possible integrated action exerted by ORs and the GABA(A) receptor-mediated system in the IC on panic-like responses. Methods: The effect of the blockade of either mu(1)- or kappa-ORs in the IC was evaluated in the unconditioned fear-induced responses elicited by GABA(A) antagonism with bicuculline. Microinjections of naloxonazine, a mu(1)-OR antagonist, or nor-binaltorphimine (nor-BNI), a kappa-OR antagonist, were made into the IC, followed by intramesencephalic administration of the GABA(A)-receptor antagonist bicuculline. The defensive behaviours elicited by the treatments in the IC were quantitatively analysed, recording the number of escapes expressed as running (crossing), jumps, and rotations, over a 30-min period in a circular arena. The exploratory behaviour of rearing was also recorded. Results: GABA(A)-receptor blockade with bicuculline in the IC increased defensive behaviours. However, pretreatment of the IC with higher doses (5 mu g) of naloxonazine or nor-BNI followed by bicuculline resulted in a significant decrease in unconditioned fear-induced responses. Conclusions: These findings suggest a role played by mu(1)- and kappa-OR-containing connexions and GABA(A) receptor-mediated neurotransmission on the organisation of panic attack-related responses elaborated by the IC neurons. (AU) | |
| FAPESP's process: | 09/54014-7 - Acquisition of a biophotonic imaging system and a multiphoton microscopy system for in vivo imaging |
| Grantee: | Enilza Maria Espreafico |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 12/23238-0 - Evaluation of cooperative mechanisms between opioidergic and serotonergic systems in the dorsal periaqueductal grey matter in the antidepressants effects |
| Grantee: | Camila Marroni Roncon |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 15/10313-1 - Study of nigro-tectal GABAergic pathways activity during the elaboration of defensive behaviour: role of endocannabinoid mediated neuromodulation in the caudatum putamen of the GABAergic disinhibitory neostriatum-nigral inhibitory nigro-collicular pathways |
| Grantee: | Juliana Almeida da Silva |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 09/02458-9 - Neuropharmacological study of the interaction between cannabinoid and opioid circuits of the substantia nigra, pars reticulata, on the activity of the nigrotectal GABAergic pathways, and of its role in the modulation of the innate fear-induced analgesia |
| Grantee: | Juliana Almeida da Silva |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 07/01174-1 - Study of the Involvement of opioid-, serotonergic- and noradrenergic-mechanisms of the pain endogenous inhibitory system in antinociceptive processes induced by oriented escape reactions evoked by chemical stimulation of the merdial hypothalamus |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/25167-2 - Role of glutamatergic, endocannabinoid and endovaniloid systems of medial pre-frontal cortex in neurophatic pain model: Investigation of panic and chronic pain comorbidity |
| Grantee: | Priscila Medeiros de Freitas |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/03798-0 - Involvement of opioid and endocanabinoid receptors of the substantia nigra on the activity of Nigro-Tectal GABAergic pathways during defensive behaviour elicited by rodents confronted with venomous snakes |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/13560-5 - Effect of deep brain stimulation and cannabidiol treatment in the subthalamic nucleus on the motors and non-Motors symptoms in the experimental model of Parkinson Disease |
| Grantee: | Priscila Medeiros de Freitas |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 12/22681-7 - Involvement of Opioid and Endocanabinoid Receptors of the Substantia Nigra, Pars Reticulata, in the Modulation of the Activity of Nigro-Tectal GABAergic Pathways during the Organization of Defensive Behaviour of Mice Confronted with Venomous Snakes |
| Grantee: | Rafael Carvalho Almada |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |