The Human Milk Microbiota is Modulated by Maternal Diet

Author(s):Show less -

Padilha, Marina ^{[1, 2]} ; Danneskiold-Samsoe, Niels Banhos ^[3] ; Brejnrod, Asker ^[3] ; Hoffmann, Christian ^{[1, 2]} ; Cabral, Vanessa Pereira ^{[1, 4]} ; Iaucci, Julia de Melo ^[1] ; Sales, Cristiane Hermes ^[4] ; Fisberg, Regina Mara ^[4] ; Cortez, Ramon Vitor ^[1] ; Brix, Susanne ^[5] ; Taddei, Carla Romano ^{[6, 1]} ; Kristiansen, Karsten ^[3] ; Isay Saad, Susana Marta ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Sch Pharmaceut Sci, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Food Res Ctr FoRC, BR-05508000 Sao Paulo, SP - Brazil

^[3] Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, DK-2100 Copenhagen - Denmark

^[4] Univ Sao Paulo, Sch Publ Hlth, BR-01246904 Sao Paulo, SP - Brazil

^[5] Tech Univ Denmark, Dept Biotechnol & Biomed, DK-2800 Lyngby - Denmark

^[6] Univ Sao Paulo, Sch Arts Sci & Humanities, BR-03828000 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: MICROORGANISMS; v. 7, n. 11 NOV 2019.
• Web of Science Citations: 1

Abstract

Human milk microorganisms contribute not only to the healthy development of the immune system in infants, but also in shaping the gut microbiota. We evaluated the effect of the maternal diet during pregnancy and during the first month of lactation on the human milk microbiota in a cross-sectional study including 94 healthy lactating women. Microbiota composition was determined by 16S rDNA profiling and nutrient intake assessed through food questionnaires. Thirteen genera were present in at least 90% of all samples, with three genera present in all samples: Streptococcus, Staphylococcus, and Corynebacterium. Cluster analysis indicated two distinct compositions: one marked by a high abundance of Streptococcus (cluster 1), and other by a high abundance of Staphylococcus (cluster 2). A global association with milk microbiota diversity was observed for vitamin C intake during pregnancy (p = 0.029), which was higher for cluster 2 individuals (cluster 2 median = 232 mg/d; cluster 1 = 175 mg/d; p = 0.02). Positive correlations were found between Bifidobacterium in the milk and intake of polyunsaturated and linoleic fatty acids during the lactation period (p < 0.01). We show that maternal diet influences the human milk microbiota, especially during pregnancy, which may contribute in shaping the gut microbiota. (AU)

• FAPESP's process: 16/07936-0 - Human milk microbiota analysis by next-generation sequencing: the impact of maternal diet and the intervention with fructooligosaccharides
• Grantee: Marina Padilha
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 13/26435-3 - Impact of the maternal diet and the intervention with fructooligosaccharide on the human milk microbiota.
• Grantee: Marina Padilha
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/07914-8 - FoRC - Food Research Center
• Grantee: Bernadette Dora Gombossy de Melo Franco
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC