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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In Vitro and In Vivo Anti-Candida spp. Activity of Plant-Derived Products

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Pedroso, Reginaldo dos Santos [1, 2, 3] ; Balbino, Brenda Lorena [1] ; Andrade, Gessica [1] ; Pereira Sacardo Dias, Maria Cecilia [1] ; Alvarenga, Tavane Aparecida [1] ; Nascimento Pedroso, Rita Cassia [1] ; Pimenta, Leticia Pereira [1] ; Lucarini, Rodrigo [1] ; Pauletti, Patricia Mendonca [1] ; Januario, Ana Helena [1] ; Menezes Carvalho, Marco Tulio [4] ; Dantas Miranda, Mayker Lazaro [5] ; Pires, Regina Helena [1]
Total Authors: 13
[1] Univ Franca, BR-14404600 Franca, SP - Brazil
[2] Univ Fed Uberlandia, Escola Tecn Saude, BR-38400902 Uberlandia, MG - Brazil
[3] Univ Fed Uberlandia, Programa Posgrad Ciencias Saude, BR-38400902 Uberlandia, MG - Brazil
[4] Univ Estadual Minas Gerais, BR-37902407 Passos, MG - Brazil
[5] Inst Fed Triangulo Mineiro, Campus Uberlandia Ctr, BR-38064300 Uberlandia, MG - Brazil
Total Affiliations: 5
Document type: Journal article
Source: PLANTS-BASEL; v. 8, n. 11 NOV 2019.
Web of Science Citations: 0

Candidiasis therapy, especially for candidiasis caused by Candida non-albicans species, is limited by the relatively reduced number of antifungal drugs and the emergence of antifungal tolerance. This study evaluates the anticandidal activity of 41 plant-derived products against Candida species, in both planktonic and biofilm cells. This study also evaluates the toxicity and the therapeutic action of the most active compounds by using the Caenorhabditis elegans-Candida model. The planktonic cells were cultured with various concentrations of the tested agents. The Cupressus sempervirens, Citrus limon, and Litsea cubeba essential oils as well as gallic acid were the most active anticandidal compounds. Candida cell re-growth after treatment with these agents for 48 h demonstrated that the L. cubeba essential oil and gallic acid displayed fungistatic activity, whereas the C. limon and C. sempervirens essential oils exhibited fungicidal activity. The C. sempervirens essential oil was not toxic and increased the survival of C. elegans worms infected with C. glabrata or C. orthopsilosis. All the plant-derived products assayed at 250 mu g/mL affected C. krusei biofilms. The tested plant-derived products proved to be potential therapeutic agents against Candida, especially Candida non-albicans species, and should be considered when developing new anticandidal agents. (AU)

FAPESP's process: 18/02333-0 - Assessment in vitro and in vivo of the effects of vegetal products against free-living and biofilm growth mode of Candida
Grantee:Regina Helena Pires
Support Opportunities: Regular Research Grants
FAPESP's process: 18/20828-7 - Evaluation of in vitro effects of plants derivatives on yeast cells
Grantee:Maria Cecília Pereira Sacardo Dias
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/26517-0 - Evaluation of antifungal activity of essential oils against different species of Candida
Grantee:Brenda Lorena Balbino
Support Opportunities: Scholarships in Brazil - Scientific Initiation