Heat Shock Proteins in Glioblastoma Biology: Where Do We Stand?

Author(s)

Iglesia, Rebeca Piatniczka ^[1] ; de Lima Fernandes, Camila Felix ^[1] ; Coelho, Barbara Paranhos ^[1] ; Prado, Mariana Brandao ^[1] ; Melo Escobar, Maria Isabel ^[1] ; Dona Rodrigues Almeida, Gustavo Henrique ^[1] ; Lopes, Marilene Hohmuth ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508000 Sao Paulo, SP - Brazil

• Document type: Review article
• Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 20, n. 22 NOV 2019.
• Web of Science Citations: 0

Abstract

Heat shock proteins (HSPs) are evolutionary conserved proteins that work as molecular chaperones and perform broad and crucial roles in proteostasis, an important process to preserve the integrity of proteins in different cell types, in health and disease. Their function in cancer is an important aspect to be considered for a better understanding of disease development and progression. Glioblastoma (GBM) is the most frequent and lethal brain cancer, with no effective therapies. In recent years, HSPs have been considered as possible targets for GBM therapy due their importance in different mechanisms that govern GBM malignance. In this review, we address current evidence on the role of several HSPs in the biology of GBMs, and how these molecules have been considered in different treatments in the context of this disease, including their activities in glioblastoma stem-like cells (GSCs), a small subpopulation able to drive GBM growth. Additionally, we highlight recent works that approach other classes of chaperones, such as histone and mitochondrial chaperones, as important molecules for GBM aggressiveness. Herein, we provide new insights into how HSPs and their partners play pivotal roles in GBM biology and may open new therapeutic avenues for GBM based on proteostasis machinery. (AU)

• FAPESP's process: 18/15557-4 - Prion protein and its partners: emerging targets for glioblastoma stem cell based-therapy
• Grantee: Marilene Hohmuth Lopes
• Support type: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 17/26158-0 - Prion protein as stem regulator in glioblastoma stem cells: its role in the formation and function of multiprotein signaling platforms
• Grantee: Mariana Brandão Prado
• Support type: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 18/19320-9 - Gene profiling of embryonic stem cells haploinsufficient for STI1 in the maintenance of pluripotent status
• Grantee: Camila Felix de Lima Fernandes
• Support type: Scholarships in Brazil - Master
• FAPESP's process: 19/14952-0 - Characterization of intracellular signaling pathways modulated by the cellular prion protein on stemness maintenance in glioblastoma stem cells
• Grantee: Bárbara Paranhos Coelho
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 17/20271-0 - Role of prion protein in the dynamic of multiprotein signaling modules related to stemness of glioblastoma stem cells: its functional role and potential therapeutic target
• Grantee: Marilene Hohmuth Lopes
• Support type: Regular Research Grants
• FAPESP's process: 19/12710-9 - Role of cellular prion protein in temozolomide resistance: emphasis on processes modulated by hypoxia
• Grantee: Rebeca Piatniczka Iglesia
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 19/11097-1 - Modulation of the neural phenotype of glioblastoma stem cells by extracellular miRNA from NSCs
• Grantee: Maria Isabel Melo Escobar
• Support type: Scholarships in Brazil - Master