| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Univ Sao Paulo, Inst Phys, Appl Phys Dept, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Chem, Biochem Dept, Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Biophysical Chemistry; v. 254, NOV 2019. |
| Web of Science Citations: | 2 |
| Abstract | |
In this review, we describe how photooxidation changes membrane properties that can ultimately lead to permanent membrane damage. Lipid photooxidation occurs in the presence of reactive oxygen species such as singlet oxygen and by direct reactions of lipids with a photosensitizer in the excited state. Indeed, lipid oxidation triggers chemical transformations that can alter lipid packing; change the membrane surface area, thickness and elastic modulus; and induce pore formation and phase separation. Here, we highlight how lipid hydroperoxides promote membrane remodelling and phase separation. Further, we emphasize the alterations caused by truncated oxidized lipids that lead to increased membrane permeability. Finally, the consequences of lipid photooxidation on cell functions are also discussed. (AU) | |
| FAPESP's process: | 14/20107-7 - Lipid oxidation in membrane and cell biophysics: from functional nanosensors to impact on amyloid formation. Application of advanced fluorescence, X-ray scattering and microscopy techniques |
| Grantee: | Rosangela Itri |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/23071-9 - Photosensitization in lysosomal mimetic membranes to investigate the cell death mechanism related to autophagy. |
| Grantee: | Tayana Mazin Tsubone |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |