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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

cis-bis(N-benzoyl-N `,N `-dibenzylthioureido) platinum(II): Synthesis, molecular structure and its interaction with human and bovine serum albumin

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Author(s):
Correa, Rodrigo S. [1] ; Oliveira, Katia M. [2] ; Perez, Hiram [3] ; Plutin, Ana M. [4] ; Ramos, Raul [4] ; Mocelo, Raul [4] ; Castellano, Eduardo E. [5] ; Batista, Alzir A. [2]
Total Authors: 8
Affiliation:
[1] Univ Fed Ouro Preto, ICEB, Dept Quim, BR-35400000 Ouro Preto, MG - Brazil
[2] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP - Brazil
[3] Univ Habana, Fac Quim, Dept Quim Inorgan, Havana 10400 - Cuba
[4] Univ Habana, Fac Quim, Lab Sintesis Organ, Havana 10400 - Cuba
[5] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: ARABIAN JOURNAL OF CHEMISTRY; v. 12, n. 8, p. 3454-3462, DEC 2019.
Web of Science Citations: 8
Abstract

In this paper, the title compound was synthesized from N-benzoyl-N',N'-dibenzyl thiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X-ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N',N'-dibenzylthiourea ligands in a distorted square-planar geometry. In the solid state, Hirshfeld surface analysis emphasizes that the molecules are connected by non-classical C-H center dot center dot center dot C, C-H center dot center dot center dot S and H center dot center dot center dot H intermolecular contacts. These weak interactions can be mainly responsible due to complex-BSA and complex-HSA binding. The complex interacts differently with HSA and BSA such as observed by the binding constant, K-b, presenting values of around 10(5) M-1 and 10(4) M-1, respectively. Thermodynamic parameters (Delta G, Delta H and Delta S) suggest spontaneous interactions between complex and the proteins. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University. (AU)

FAPESP's process: 13/26559-4 - Structural modifications in biologically active Ru(II) complexes toward the design of new metallodrug candidates
Grantee:Rodrigo de Souza Corrêa
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/04147-9 - Evaluation of anticancer properties of ruthenium(II)complexes containing lapachol and lawsone bioligands
Grantee:Katia Mara de Oliveira
Support type: Scholarships in Brazil - Doctorate