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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Linkage disequilibrium and effective population size in Gir cattle selected for yearling weight

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Toro Ospina, Alejandra M. [1] ; Maiorano, Amanda Marchi [1] ; Curi, Rogerio A. [2] ; Pereira, Guilherme L. [2] ; Zerlotti-Mercadante, Maria Eugenia [3] ; dos Santos Goncalves Cyrillo, Joslaine Noely [3] ; Aspilcueta-Borquis, Rusbel R. [4] ; Silva, II, Josineudson A. de V.
Total Authors: 8
[1] Sao Paulo State Univ, Fac Agr & Vet Sci, Genet Anim Breeding, Jaboticabal, SP - Brazil
[2] II, Sao Paulo State Univ, Fac Vet Med & Anim Sci, Dept Breeding & Anim Nutr, Botucatu, SP - Brazil
[3] Inst Anim Sci, Ctr Beef Cattle, Sertaozinho - Brazil
[4] Fed Univ Grande Dourados, Fac Agr Sci, Dourados - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 1

Linkage disequilibrium (LD) plays an important role in genomic selection and mapping of quantitative trait loci (QTL). This study investigated the pattern of LD and effective population size (N-e) in Gir cattle selected for yearling weight. For this purpose, 173 animals with imputed genotypes (from 18 animals genotyped with the Illumina BovineHD BeadChip and 155 animals genotyped with the Bovine LDv4 panel) were analysed. The LD was evaluated at distances of 25-50 kb, 50-100 kb, 100-500 kb and 0.5-1 Mb. The N-e was estimated based on 5 past generations. The r(2) values (a measure of LD) were, respectively, .35, .29, .18 and .032 for the distances evaluated. The LD estimates decreased with increasing distance of SNP pairs and LD persisted up to a distance of 100 kb (r(2) = .29). The N-e was greater in generations 4 and 5 (24 and 30 animals, respectively) and declined drastically after the last generation (12 animals). The results showed high levels of LD and low N-e, which were probably due to the loss of genetic variability as a consequence of the structure of the Gir population studied. (AU)

FAPESP's process: 15/06686-7 - Population structure evaluation of Gir cattle selected for meat and milk through SNPs arrays
Grantee:Josineudson Augusto Ii de Vasconcelos Silva
Support Opportunities: Regular Research Grants