The Controversial Role of Autophagy in Tumor Development: A Systematic Review

Author(s)

Colhado Rodrigues, Bridilla Luiza ^{[1, 2]} ; Lallo, Maria Anete ^[2] ; Perez, Elizabeth Cristina ^[2]

Affiliation

^[1] Inst Butantan, Lab Imunogenet, Sao Paulo, SP - Brazil

^[2] Univ Paulista, Programa Posgrad Patol Ambiental & Expt, Rua Doutor Bacelar 1212, 4th Floor, BR-04026002 Sao Paulo, SP - Brazil

• Document type: Review article
• Source: IMMUNOLOGICAL INVESTIGATIONS; v. 49, n. 4 NOV 2019.
• Web of Science Citations: 1

Abstract

Autophagy is a natural regulatory mechanism of the cell that eliminates unnecessary and dysfunctional cellular components to maintain homeostasis. Several authors have demonstrated that this mechanism can be induced by pathological conditions as cancer. However, their role in tumor development is still a controversial issue in cancer research. Here, we discussed the most relevant findings concerning autophagy in tumor development. In this critical review performed with studies published between 2002 and 2018, we found that the main pathway involved in the autophagy process is the PI3K/AKT/mTOR intracellular signaling pathway. Regarding their role in cancer development, breast cancer is the main study target, followed by lung, prostate and colon cancer. In these issues, 46% of the works consulted suggesting that autophagy inhibits tumor progression by favor a better antitumor response, 4% suggest that favors growth and tumor progression and, 50% of the authors failed to establish whether autophagy inhibits or favors tumor development. Herein, we concluded that depending on the study model, autophagy may favor or inhibits growth and cancer progression. (AU)

• FAPESP's process: 17/04176-7 - Influence of AhR gene on the development of ulcerative colitis by sodium sulfate of dextran in animal model of acute inflammation
• Grantee: Bridilla Luiza Colhado Rodrigues
• Support type: Scholarships in Brazil - Scientific Initiation