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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

SMARCB1 (INI-1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center

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Neves-Silva, Rodrigo [1] ; Almeida, Luciana Y. [2] ; Silveira, Heitor A. [1, 2] ; Colturato, Carla B. N. [1] ; Duarte, Andressa [3] ; Ferrisse, Tulio M. [2] ; Silva, V, Evanio ; Vanzolin, Barbara F. [1] ; Bufalino, Andreia [4] ; Ribeiro-Silva, Alfredo [3] ; Leon, Jorge E. [1]
Total Authors: 11
[1] Univ Sao Paulo, Ribeirao Preto Dent Sch FORP, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol, BR-14040904 Ribeirao Preto, SP - Brazil
[2] Sao Paulo State Univ UNESP, Araraquara Dent Sch, Dept Diag & Surg, Araraquara, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch FMRP, Dept Pathol & Forens Med, Ribeirao Preto, SP - Brazil
[4] Silva, Evanio, V, Sao Paulo State Univ UNESP, Araraquara Dent Sch, Dept Diag & Surg, Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

Background SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas are aggressive neoplasms, often affecting the sinonasal region. Not uncommonly, their diagnoses are made retrospectively. Methods Through SMARCB1 (INI-1) and NUT immunomarkers, 643 head and neck carcinomas were assessed retrospectively. Moreover, SMARCB1 (INI-1)-deficient and NUT carcinomas were additionally evaluated by immunohistochemistry, as well as in situ hybridization analysis for HPV and EBV. Results Four SMARCB1 (INI-1)-deficient carcinomas (located in lower lip, soft palate, hypopharynx and vocal cord, this latter high-risk HPV positive) and three NUT carcinomas (all located in oropharynx) were detected, previously diagnosed as nonkeratinizing or moderately differentiated squamous cell carcinoma. All cases showed squamous differentiation. NUT carcinomas than SMARCB1 (INI-1)-deficient carcinomas showed low overall survival rate. Conclusion The current cases expand the clinicopathological spectrum of SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas. Notably, the diagnosis of these cases is easily reached through immunohistochemistry, with impact on their accurate classification, treatment, and prognosis. (AU)

FAPESP's process: 18/12734-2 - Comparative immunohistochemical characterization of dendritic cell subgroups and viral oncogenesis in oral and oropharyngeal squamous cell carcinoma
Grantee:Heitor Albergoni da Silveira
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region
Grantee:Jorge Esquiche León
Support type: Regular Research Grants
FAPESP's process: 16/02713-2 - Effects of erlotinib and gefitinib therapy in combination with all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: in vitro, ex vivo and murine experimental model studies.
Grantee:Luciana Yamamoto de Almeida
Support type: Scholarships in Brazil - Post-Doctorate